6 documents found, page 1 of 1
Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ...
Silva, Luiz Francisco Rocha e; Montoia, Andréia; Amorim, Rodrigo C.N.; Melo, Márcia R.S.; Henrique, Marycleuma Campos; Nunomura, Sergio MassayoshiIndole alkaloids ellipticine (1), cryptolepine triflate (2a), rationally designed 11-(4-piperidinamino)cryptolepine hydrogen dichloride (2b) and olivacine (3) (an isomer of 1) were evaluated in vitro against Plasmodium falciparum and in vivo in Plasmodium berghei-infected mice. 1-3 inhibited P. falciparum (IC50 ≤ 1.4 μM, order of activity: 2b > 1 > 2a > 3). In vitro toxicity to murine macrophages was evaluated ...
Biological activity of neosergeolide and isobrucein B (and two semi-synthetic d...
Silva, Ellen Cristina Costa; Coelho Cavalcanti, Bruno; Amorim, Rodrigo C.N.; Lucena, Jorcilene F.; Quadros, Dulcimar S.; Tadei, Wanderli PedroIn the present study, in vitro techniques were used to investigate a range of biological activities of known natural quassinoids isobrucein B (1) and neosergeolide (2), known semi-synthetic derivative 1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative, 12-acetylneosergeolide (4). These compounds were evaluated for general toxicity toward the brine shrimp species Artemia franciscana, cytotoxicity...
In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon
Lima, Renata Braga Souza; Rocha Silva, Luiz F.; Melo, Márcia R.S.; Costa, Jacqueline S.; Picanço, Neila Soares; Lima, Emerson SilvaBackground: The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. and Artemisia annua, respectively). The synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. Malaria is endemic to the Amazon region where Plasmodium falciparum and Plasmodium vivax drug-re...
In vitro and in vivo anti-malarial activity of limonoids isolated from the resi...
Pereira, Tiago B.; Silva, Luiz Francisco Rocha e; Amorim, Rodrigo C.N.; Melo, Márcia R.S.; Zacardi de Souza, Rita C.; Eberlin, M. N.Background: Carapa guianensis is a cultivable tree used by traditional health practitioners in the Amazon region to treat several diseases and particularly symptoms related to malaria. Abundant residual pressed seed material (RPSM) results as a by-product of carapa or andiroba oil production. The objective of this study was to evaluate the in vitro and in vivo anti-malarial activity and cytotoxicity of limonoid...
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazon...
Andrade Neto, Valter Ferreira de; Pohlit, Adrian Martin; Pinto, Ana Cristina da Silva; Silva, Ellen Cristina Costa; Nogueira, Karla LagosIn the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more activ...
Polysaccharide isolated from Agardhiella ramosissima : chemical structure and a...
Batista, Jalles A.; Dias, Eulina G.N.; Brito, Tarcisio V.; Prudêncio, Rafael S.; Silva, Renan O.; Ribeiro, Ronaldo A.; Souza, Marcellus Henrique L.P.The sulfated polysaccharide (PLS) fraction of Agardhiella ramosissima was characterized by microanalysis, infrared spectroscopy, NMR and gas–liquid-chromatography–mass-spectrometry. The main constituent of PLS was the carrageenan. The monosaccharide composition of the PLS showed galactose, 3,6- anhydrogalactose and 6-O-methylgalactose. The PLS (30 mg kg−1) significantly reduced the paw oedema induced by carrage...