8 documents found, page 1 of 1
Efeitos anti-hiperalgésico e anti-inflamatório da Kielmeyera rugosa Choisy (Clu...
Melo, Mônica Santos dePlants of the genus Kielmeyera, family Clusiaceae are used by the population of the Northeast of the Brazil in traditional medicine to treat various diseases, such as pain and inflammation diseases. A recent study demonstrated antitumor activity for K. rugosa, however, other pharmacological activities have never been studied, for example antihyperalgesic and anti inflammatory activities. Thus, the aim of this s...
Hyptis pectinata gel prevents alveolar bone resorption in experimental periodon...
Paixão, Mônica Silveira; Melo, Mônica Santos de; Damascena, Nicole Prata; Araujo, Adriano Antunes de Souza; Soares, Andrea FerreiraHyptis pectinata (L.) Poit., Lamiaceae, is an aromatic, abundant and broadly used plant species in Sergipe to treat oral and gastrointestinal pain and inflammation. The aim of the present study was to analyze the relation between periodontitis and changes in the corporal mass and alveolar bone structure after induction of experimental periodontal disease in rat treated or not treated with H. pectinata gel at 5%...
Anti-inflammatory and redox-protective activities of citronellal
Melo, Mônica Santos de; Guimarães, Adriana Gibara; Santana, Michele Fraga de; Barreto, Rosana de Souza Siqueira; Lima, Amanda do Carmo Bion deThe anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p < 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan- and arachidonic acid-induced rat hind paw edema was significantly inhibited (p < 0.05) by i.p. admi...
Phytochemical screening, antinociceptive and anti-inflammatory activities of Ch...
Lima, Gabrielle Mendes; Quintans-Júnior, Lucindo José; Thomazzi, Sara Maria; Almeida, Emyle Mayra Santana Alves; Melo, Mônica Santos deChrysopogon zizanioides (L.) Roberty, Poaceae, is a plant widely used in northeast Brazil in folk medicine for the treatment of various pathological conditions, including inflammatory pain. The present study evaluated the antinociceptive and anti-inflammatory effects of C. zizanioides essential oil (EO) in rodents. EO was further characterized by GC/MS. The major components of EO were identified as khusimol (19...
p-Cymene reduces orofacial nociceptive response in mice
Santana, Michele Fraga de; Quintans-Júnior, Lucindo José; Cavalcanti, Sócrates Cabral de Holanda; Oliveira, Makson Gleydson Brito deThis study investigated the possible antinociceptive effect of p-cymene in different tests of orofacial nociception. The animals (mice) were pretreated (i.p.) with p-cymene (25, 50, 100 mg/kg), morphine (5 mg/kg), or vehicle (0.2% Tween 80+saline), and were then subsequently administered, subcutaneously into their upper lip: formalin, capsaicin, and glutamate. The nociceptive behavior response was characterized...
Bioassay-guided evaluation of central nervous system effects of citronellal in ...
Melo, Mônica Santos de; Souza, Marilia Trindade de Santana; Guimarães, Adriana Gibara; Barreto, Rosana de Souza SiqueiraThe central nervous system (CNS) depressant and anticonvulsant activities of citronellal (CT) were investigated in animal models. The CT in doses of 100, 200 and 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group. The highest dose of CT significantly reduced the remaining time of the animals on the Rota-rod apparatus up to...
Antinociceptive and anti-inflammatory effects of the essential oil of Eugenia c...
Guimarães, Adriana Gibara; Melo, Mônica Santos de; Bonfim, Rangel Rodrigues; Passos, Luiz Oliveira; Machado, Samisia Maria FernandesEugenia candolleana DC. (Myrtaceae), conhecida popularmente como "murta" ou "murtinha", é uma espécie vegetal sem estudos químicos e farmacológicos descritos na literatura, distribuída no Nordeste brasileiro, principalmente, na Zona da Mata. Na medicina popular do Estado de Sergipe é utilizada no tratamento de distúrbios febris e da dor. O presente estudo buscou avaliar as possíveis atividades antinociceptiva e...
Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nocicepti...
Venâncio, Antônio Medeiros; Marchioro, Murilo; Estevam, Charles dos Santos; Melo, Mônica Santos de; Santana, Marília Trindade deThe present study investigated the antinociceptive effects of Ocimum basilicum L. (Lamiaceae) leaf essential oil (LEO) and (-)-linalool (LIN) in formalin (2%)-, glutamate (25 µM)- and capsaicin (2.5 µg)- induced orofacial nociception models in mice. The involvement of these substances was further evaluated on the neuronal excitability of the hippocampal dentate gyrus. Male mice (n=8/group) were pretreated separ...