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Chemical composition, antinociceptive, anti-inflammatory and redox properties i...
Rabelo, Alessandra Silva; Serafini, Mairim Russo; Rabelo, Thallita Kelly; Melo, Marcelia Garcez Dória de; Prado, Douglas da Silva; Gelain, Daniel PensMethods: The essential oil from the roots and rhizomes of RMO were obtained by hydrodistillation using a Clevenger apparatus, and analyzed by gas chromatography/mass spectrometry (GC/MS). Here, we evaluated free radical scavenging activities and antioxidant potential of RMO using in vitro assays for scavenging activity against hydroxyl radicals, hydrogen peroxide, superoxide radicals, and nitric oxide. The tota...
Purification, physicochemical properties, thermal analysis and antinociceptive ...
Melo, Marcelia Garcez Dória de; Araújo, Adriano Antunes de Souza; Rocha, Carla Paula Leite; Almeida, Emyle Mayra Santana AlvesLichens and their secondary metabolites have attracted the interest of many researchers. Some species have been shown to contain substances with remarkable biologic activity, as antimicrobial, mainly against Gram positive bacteria; antineoplasic acting on solid and ascetic tumors, or in culture cells; antiviral; hypotensive; and spasmolytic effects. The aim of this study was to isolate and characterize atranori...
Anti-inflammatory and toxicity studies of atranorin extracted from Cladina kalb...
Melo, Marcelia Garcez Dória de; Araújo, Adriano Antunes de Souza; Serafini, Mairim Russo; Carvalho, Larissa Feitosa; Bezerra, Marília dos SantosAtranorin (ATR) is the main compound from the lichen Cladina kalbii Ahti, which grows in the arid regions of northeastern Brazil. This study was conducted to evaluate the anti-inflammatory and toxicological properties of ATR. To evaluate anti-inflammatory properties, paw edema was induced by injecting 0.1 mL of carrageenan into the subplantar region of the right hind paw of rats, and leukocyte migration was ind...
Valores de referência hematológicos e bioquímicos de ratos (Rattus novergicus l...
Melo, Marcelia Garcez Dória de; Dória, Grace Anne Azevedo; Serafini, Mairim Russo; Araújo, Adriano Antunes de SouzaOs parâmetros hematológicos e bioquímicos podem variar entre linhagens e cepas diferentes de uma dada espécie e também em função do método de coleta de sangue. Desta forma, é fundamental determinar os valores de referência para animais de diferentes biotérios de acordo com a espécie, a dieta, a linhagem, o sexo e a idade. Foram utilizados ratos Wistar saudáveis (140-310 g) de ambos os gêneros. Foi avaliado o pe...
Pre-clinical toxicity of Morinda citrifolia Linn. leaf extract
Serafini, Mairim Russo; Santos, Rodrigo Correia; Dória, Grace Anne Azevedo; Jesus, Josepha Yohanna de; Melo, Marcelia Garcez Dória deThis investigation was carried out to evaluate the safety of an aqueous extract of Morinda citrifolia leaves (AEMC) by determining its potential toxicity after acute administration (5 g/kg) in rodents and cytotoxic studies. General behavior adverse effects and mortality were determined for up to 14 days. Biochemical and hematological parameters were determined after 14 days. Cytotoxic effects of the AEMC were d...
Anti-inflammatory and toxicity studies of atranorin extracted from Cladina kalb...
Melo, Marcelia Garcez Dória de; Araújo, Adriano Antunes de Souza; Serafini, Mairim Russo; Carvalho, Larissa Feitosa; Bezerra, Marília SantosAtranorin (ATR) is the main compound from the lichen Cladina kalbii Ahti, which grows in the arid regions of northeastern Brazil. This study was conducted to evaluate the anti-inflammatory and toxicological properties of ATR. To evaluate anti-inflammatory properties, paw edema was induced by injecting 0.1 mL of carrageenan into the subplantar region of the right hind paw of rats, and leukocyte migration was ind...