16 documents found, page 1 of 2

Leishmania diversity in bats from an endemic area for visceral and cutaneous le...

Effectiveness of an immunohistochemical protocol for Leishmania detection in di...

Universidade Federal de Minas Gerais. Instituto de Ci?ncias Biol?gicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brazil.; Funda??o Oswaldo Cruz. Centro de Pesquisas Ren? Rachou. Belo Horizonte, MG, Brazil.; Universidade Federal de Minas Gerais. Instituto de Ci?ncias Biol?gicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brazil.; Universidade Federal de Minas Gerais. Instituto de Ci?ncias B...

Factors associated with Visceral Leishmaniasis in an endemic area of Codó, Stat...

Background and Objectives: Visceral leishmaniasis (VL) is a disease with a high impact on public health. This study describes the epidemiological situation of VL in the Municipality of Codó, state of Maranhão, Brazil, between the years 2007-2012. Method: Initially, an analytical study was performed between the years 2007-2011, which assessed the characteristics of individuals with VL, such as: gender, age, ethn...

The influence of ecto-nucleotidases on Leishmania amazonensis infection and imm...

Previous results from our laboratory and from the literature have implicated the expression of ectonucleotidases in the establishment of Leishmania infection. In the present study we evaluated the correlation between ecto-nucleotidasic activity and the infectivity of L. amazonensis promastigotes that were kept in culture for short or extended numbers of passages, a condition that is known to decrease parasite i...

Ecto-nucleotidase activities of promastigotes from leishmania (Viannia) brazili...

Background: Leishmania (Viannia) braziliensis has been associated with a broad range of clinical manifestations ranging from a simple cutaneous ulcer to destructive mucosal lesions. Factors leading to this diversity of clinical presentations are not clear, but parasite factors have lately been recognized as important in determining disease progression. Given the fact that the activity of ecto-nucleotidases corr...

Immunotherapy, immunochemotherapy and chemotherapy for American cutaneous leish...

O tratamento de primeira escolha para leishmaniose tegumentar americana é o antimonial pentavalente. Embora este tratamento seja na maioria das vezes efetivo e indicado, devem ser consideradas as desvantagens tais como efeitos colaterais, longa duração do tratamento e contra-indicação para cardiopatas, nefropatas, idosos, grávidas e outras condições. Com o advento da vacina antileishmaniose tegumentar americana...

American tegumentary leishmaniasis : effectiveness of an immunohistochemical pr...

Background: American tegumentary leishmaniasis (ATL) is endemic in Latin America, where Brazil has over 27 thousand cases per year. The aim of the present study was to develop an immunohistochemical method (IHC) for ATL diagnosis. For this purpose, we used serum from a dog naturally infected with Leishmania (L) infantum (canine hyperimmune serum) as the primary antibody, followed by a detection system with a se...

Leishmaniose visceral canina : avaliação da metodologia sorológica utilizada em...

Foi realizado um estudo comparativo da reação de imunofluorescencia indireta em eluatos de sangue de cães infectados experimentalmente com diferentes tripanosomatideos. Utilizaram-se como antigenopromastigotas de L. mexicana, L. braziliensis e L. chagasi. Os resultados mostraram que a sensibilidade do método foi de 87,5% para o diagnostico do calazar canino, independentemente do antígeno empregado; e que ocorre...

Immunological changes in canine peripheral blood leukocytes triggered by immuni...

In this study, we summarized the major phenotypic/functional aspects of circulating leuko-cytes following canine immunization with Leishvaccine and Leishmune ®. Our findings showed that Leishvaccine triggered early changes in the innate immunity (neutrophils and eosinophils) with late alterations on monocytes. Conversely, Leishmune ® induced early phenotypic changes in both, neutrophils and monocytes. Moreover,...

Despite Leishvaccine and Leishmune ® trigger distinct immune profiles, their ab...

Phenotypic features of peripheral blood leukocytes have been investigated as a prerequisite to characterize the protective immunity attributed to both Leishvaccine and Leishmune ® . Our results showed that either those vaccine were accompanied by distinct profiles on innate immune compartment. While Leishvaccine promoted early changes in phenotypic fea-tures of neutrophils and eosinophils with late involvement ...