2 documents found, page 1 of 1
A Protocol for FRET-Based Live-Cell Imaging in Microglia
Socodato, R; Melo, PN; Ferraz-Nogueira, JP; Portugal, CC; Relvas, JBThis protocol highlights the use of FRET-based biosensors to investigate signaling events during microglia activation in real time. Understanding microglia activation has gained momentum as it can help decipher signaling mechanisms underlying the neurodegenerative process occurring in neurological disorders. Unlike more traditional methods widely employed in the microglia field, FRET allows microglia signaling ...
Emerging biosensing technologies for neuroinflammatory and neurodegenerative di...
Abreu, C; Soares-Dos-Reis, R; Melo, PN; Relvas, JB; Guimarães, J; Sá, M; Cruz, AP; Pinto, INeuroinflammation plays a critical role in the onset and progression of many neurological disorders, including Multiple Sclerosis, Alzheimer’s and Parkinson’s diseases. In these clinical conditions the underlying neuroinflammatory processes are significantly heterogeneous. Nevertheless, a common link is the chronic activation of innate immune responses and imbalanced secretion of pro and anti-inflammatory media...