8 documents found, page 1 of 1
New Prospects for the Management of Cardiovascular Effects of Tyrosine Kinase I...
Almeida, A; Almeida, A; Melo, T; Guerra, L; Lopes, L; Ribeiro, P; Duarte, M; Mota, A; Fontes-Carvalho, RThe use of tyrosine kinase inhibitors (TKIs) for the treatment of chronic myeloid leukemia has significantly altered the prognosis of this disease, enabling close to normal life expectancy. Despite their undeniable benefits, the use of TKIs is associated with an increased risk of side effects on the cardiovascular system, particularly of atherothrombotic events. It is therefore necessary to understand and preve...
Errors in protein synthesis increase the level of saturated fatty acids and aff...
Araújo, A; Melo, T; Maciel, E; Pereira, C; Morais, C; Santinha, D; Tavares, J; Oliveira, H; Jurado, A; Costa, V; Domingues, P; Domingues, M; Santos, MThe occurrence of protein synthesis errors (mistranslation) above the typical mean mistranslation level of 10−4 is mostly deleterious to yeast, zebrafish and mammal cells. Previous yeast studies have shown that mistranslation affects fitness and deregulates genes related to lipid metabolism, but there is no experimental proof that such errors alter yeast lipid profiles. We engineered yeast strains to misincorpo...
Laterality of Pneumonia in Acute Stroke
Alves, P; Silva, C; Baptista, J; Lima, B; Jacinto, M; Trigueiros, F; Martins, A; Melo, T; Fonseca, ACBACKGROUND/AIMS: Previous studies demonstrated an alteration of diaphragmatic excursion on the paretic side after stroke; however, it is unclear if this change has clinical repercussions. We aimed to determine if there was an association between the paretic side and the laterality of pneumonia after stroke. METHODS: A retrospective analysis of a consecutive cohort of patients admitted to a stroke unit from 2008...
Mergulho...Praia...Piscina...Que Consequências?
Dias, E; Salvado, M; Salvado, P; Melo, T
Diving...Beach...Swimming-Pool...What Consequences?
Dias, E; Salvado, M; Salvado, P; Melo, T
Diving...Beach...Swimming-Pool...What Consequences?
Dias, E; Salvado, M; Salvado, P; Melo, T
Mergulho...Praia...Piscina...Que Consequências?
Dias, E; Salvado, M; Salvado, P; Melo, T
Diagnosis of stroke by the nonneurologist: a validation study.
Ferro, J; Pinto, A; Falcão, I; Rodrigues, G; Ferreira, J; Falcão, F; Azevedo, E; Canhão, P; Melo, T; Rosas, MJ; Oliveira, V; Salgado, AVBACKGROUND AND PURPOSE: The first medical contact of an acute stroke victim is often a nonneurologist. Validation of stroke diagnosis made by these medical doctors is poorly known. The present study seeks to validate the stroke diagnoses made by general practitioners (GPs) and hospital emergency service physicians (ESPs). METHODS: Validation through direct interview and examination by a neurologist was performe...