23 documents found, page 1 of 3

Validação de um método analítico para a determinação de antidepressivos em amos...

O consumo dos antidepressivos (AD) na última década tem vindo a aumentar e, portanto, a solicitação para a sua deteção em amostras biológicas no Serviço de Química e Toxicologia Forense (SQTF) tem sido cada vez maior. Por este motivo, é necessário que haja uma contínua evolução científica de técnicas de deteção e a respetiva validação de forma a acompanhar este crescimento. Este trabalho teve como objetivo a va...

Global impact of the COVID-19 pandemic on stroke volumes and cerebrovascular ev...

Background and objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of str...

Cerebral venous thrombosis as a first presentation of a high-risk acute myeloid...

Nationwide Access to Endovascular Treatment for Acute Ischemic Stroke in Portugal

Introduction: Since the publication of endovascular treatment trials and European Stroke Guidelines, Portugal has re-organized stroke healthcare. The nine centers performing endovascular treatment are not equally distributed within the country, which may lead to differential access to endovascular treatment. Our main aim was to perform a descriptive analysis of the main treatment metrics regarding endovascular ...

Clinical presentation and neural correlates of stroke‐associated spatial delusions

Background and purpose: Incongruent beliefs about self-localization in space markedly disturb patients' behavior. Spatial delusions, or reduplicative paramnesias, are characterized by a firm conviction of place reduplication, transformation, or mislocation. Evidence suggests they are frequent after right hemisphere lesions, but comprehensive information about their clinical features is lacking. Methods: We pros...

Global impact of COVID-19 on stroke care and IV thrombolysis

Objective: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified ...

Mean platelet volume is a prognostic marker in acute ischemic stroke patients t...

Background and objectives: There is conflicting data regarding the association between platelet parameters and prognosis of stroke patients treated with intravenous thrombolysis. We aimed to analyze this association in a cohort of patients treated with rtPA. Material and methods: Retrospective, observational study in adult ischemic stroke patients treated with rtPA between January 2015 and February 2017. Demogr...

Unravelling the neural basis of spatial delusions after stroke

Objective: Knowing explicitly where we are is an interpretation of our spatial representations. Reduplicative paramnesia is a disrupting syndrome in which patients present a firm belief of spatial mislocation. Here, we studied the largest sample of patients with delusional misidentifications of space (i.e. reduplicative paramnesia) after stroke to shed light on their neurobiology. Methods: In a prospective, cum...

Synthesis and structure-activity relationships of new chiral spiro-β-lactams hi...

The synthesis and antimicrobial activity of new spiro-β-lactams is reported. The design of the new molecules was based on the structural modulation of two previously identified lead spiro-penicillanates with dual activity against HIV and Plasmodium. The spiro-β-lactams synthesized were assayed for their in vitro activity against HIV-1, providing relevant structure-activity relationship information. Among the te...

Aphasia assessment: impact of material on naming performance

Background: Naming and lexical retrieval difficulties are common symptoms of aphasia. Naming abilities are usually evaluated by means of real objects or pictures or line drawings that are printed. Objective: The aim of this study was to investigate whether the ability to name objects among individuals with aphasia is influenced by the dimensions of the visual stimuli and to understand whether the order of prese...