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CD4+ T cell vaccination overcomes defective cross-presentation of fungal antige...
Luca, Antonella De; Iannitti, Rossana G.; Bozza, Silvia; Beau, Remi; Casagrande, Andrea; D’Angelo, Carmen; Moretti, Silvia; Cunha, CristinaAspergillus fumigatus is a model fungal pathogen and a common cause of infection in individuals with the primary immunodeficiency chronic granulomatous disease (CGD). Although primarily considered a deficiency of innate immunity, CGD is also linked to dysfunctional T cell reactivity. Both CD4+ and CD8+ T cells mediate vaccine-induced protection from experimental aspergillosis, but the molecular mechanisms leadi...
Date: 2012
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Origin: RepositóriUM - Universidade do Minho