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Hyptis pectinata gel prevents alveolar bone resorption in experimental periodon...
Paixão,Mônica S.; Melo,Mônica S.; Damascena,Nicole P.; Araújo,Adriano A.S.; Soares,Andrea F.; Oliveira,Denise V.A.; Oliveira,Jeison S.Hyptis pectinata (L.) Poit., Lamiaceae, is an aromatic, abundant and broadly used plant species in Sergipe to treat oral and gastrointestinal pain and inflammation. The aim of the present study was to analyze the relation between periodontitis and changes in the corporal mass and alveolar bone structure after induction of experimental periodontal disease in rat treated or not treated with H. pectinata gel at 5%...
Phytochemical screening, antinociceptive and anti-inflammatory activities of Ch...
Lima,Gabrielle M.; Quintans-Júnior,Lucindo J.; Thomazzi,Sara M.; Almeida,Emyle M. S. A.; Melo,Mônica S.; Serafini,Mairim R.; Cavalcanti,Sócrates C. H.Chrysopogon zizanioides (L.) Roberty, Poaceae, is a plant widely used in northeast Brazil in folk medicine for the treatment of various pathological conditions, including inflammatory pain. The present study evaluated the antinociceptive and anti-inflammatory effects of C. zizanioides essential oil (EO) in rodents. EO was further characterized by GC/MS. The major components of EO were identified as khusimol (19...
Bioassay-guided evaluation of central nervous system effects of citronellal in ...
Melo,Mônica S.; Santana,Marilia T. de; Guimarães,Adriana G.; Siqueira,Rosana S.; Sousa,Damião P. De; Santos,R. V.; Bonjardim,Leonardo R.The central nervous system (CNS) depressant and anticonvulsant activities of citronellal (CT) were investigated in animal models. The CT in doses of 100, 200 and 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group. The highest dose of CT significantly reduced the remaining time of the animals on the Rota-rod apparatus up to...
Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nocicepti...
Venâncio,Antônio M.; Marchioro,Murilo; Estavam,Charles S.; Melo,Mônica S.; Santana,Marília T.; Onofre,Alexandre S.C.; Guimarães,Adriana G.The present study investigated the antinociceptive effects of Ocimum basilicum L. (Lamiaceae) leaf essential oil (LEO) and (-)-linalool (LIN) in formalin (2%)-, glutamate (25 µM)- and capsaicin (2.5 µg)- induced orofacial nociception models in mice. The involvement of these substances was further evaluated on the neuronal excitability of the hippocampal dentate gyrus. Male mice (n=8/group) were pretreated separ...
p-Cymene reduces orofacial nociceptive response in mice
Santana,Michele F.; Quintans-Júnior,Lucindo J.; Cavalcanti,Sócrates C. H.; Oliveira,Makson G. B.; Guimarães,Adriana G.; Cunha,Edisleide S.This study investigated the possible antinociceptive effect of p-cymene in different tests of orofacial nociception. The animals (mice) were pretreated (i.p.) with p-cymene (25, 50, 100 mg/kg), morphine (5 mg/kg), or vehicle (0.2% Tween 80+saline), and were then subsequently administered, subcutaneously into their upper lip: formalin, capsaicin, and glutamate. The nociceptive behavior response was characterized...
Anticonvulsant evaluation of Rauvolfia ligustrina Willd. ex Roem. & Schult....
Quintans-Júnior,Lucindo J.; Siqueira,Jullyana S.; Melo,Mônica S.; Silva,Davi A.; Morais,Liana C. S. L.; Souza,Maria de Fátima V.; Almeida,Reinaldo N.The Aim of this study was to evaluated the effects of the ethanol extract of Rauvolfia ligustrina Willd. ex Roem. & Schult., Apocynaceae, roots (EER) in animal models of epilepsy. The EER increased the latency for convulsions significantly different from control (p<0,05) and in the PTZ induced convulsions test on 62,5 mg/kg (i.p.) decreased mortality. This effect was blocked by flumazenil administration, su...
Antinociceptive and anti-inflammatory effects of the essential oil of Eugenia c...
Guimarães,Adriana G.; Melo,Mônica S.; Bonfim,Rangel R.; Passos,Luiz O.; Machado,Samísia M.F.; Ribeiro,Adauto de S.; Sobral,Marcos; Thomazzi,Sara M.Eugenia candolleana DC. (Myrtaceae), commonly known as "murta" or "murtinha", is a plant species without any chemical or pharmacological study described in the literature. It has been popularly used for the treatment of pain and fever. This report aimed to investigate the possible antinociceptive and anti-inflammatory effects of the essential oil extracted from fresh leaves of Eugenia candolleana DC. (EOEc) in ...