9 documents found, page 1 of 1
Estradiol replacement abolishes cardiovascular and intracranial changes induced...
Fernandes, Marcos Vinicius; Sá, Jéssica Matheus; Lopes, Paulo Ricardo; Sacramento, Joana F.; Patrício, João S.; Colombari, Débora Simões AlmeidaThe effects of β-estradiol (E2) on cardiovascular and intracranial responses, the renin-angiotensin-aldosterone system (RAAS) activity, and central nervous system inflammatory markers were investigated in an obesity-associated menopause model. Ovariectomized (OVX) or sham female adult Holtzman and Wistar rats were fed a high-fat diet (HFD; 46% and 60% fat from lipids) or standard diet (SD) (n = 5–6 animals/grou...
Gabaergic and opioid receptors mediate the facilitation of NaCl intake induced ...
Andrade, C. A. F.; Oliveira, Lisandra Brandino de; Franzé, Gláucia Maria Fabrício de Andrade; Luca Junior, L. A. de; Colombari, Débora Simões de AlmeidaAlpha2-adrenergic, gabaergic or opioidergic activation in the lateral parabrachial nucleus (LPBN) increases sodium intake. In the present study, we investigated the effects of single or combined block-ade of opioidergic and gabaergic receptors in the LPBN on the increase of 0.3 M NaCl intake induced by _2-adrenoceptor activation in the LPBN. Male Holtzman rats (n = 5–9/group) with cannulas implanted bilaterally...
Opioid activation in the lateral parabrachial nucleus induces hypertonic sodium...
Oliveira, Lisandra Brandino de; Luca Junior, L. A. de; Menani, José VanderleiOpioid mechanisms are involved in the control of water and NaCl intake and opioid receptors are present in the lateral parabrachial nucleus (LPBN), a site of important inhibitory mechanisms related to the control of sodium appetite. Therefore, in the present study we investigated the effects of opioid receptor activation in the LPBN on 0.3 M NaCl and water intake in rats. Male Holtzman rats with stainless steel...
Sodium intake by hyperosmotic rats treated with a GABAA receptor agonist into t...
Kimura, Everton Heidi; Oliveira, Lisandra Brandino de; Colombari, Débora Simões de Almeida; Luca Junior, L. A. de; Menani, José VanderleiInhibitory mechanisms in the lateral parabrachial nucleus (LPBN) and central GABAergic mechanisms are involved in the regulation of water and NaCl intake. Besides increasing fluid depletion-induced sodium intake, the activation of GABAA receptors with muscimol into the LPBN also induces ingestion of 0.3 M NaCl in normonatremic, euhydrated rats. It has been suggested that inhibitory mechanisms activated by osmot...
Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chlori...
Kimura, Everton Heidi; Oliveira, Lisandra Brandino de; Menani, José Vanderlei; Callera, João CarlosBackground: Activation of GABAB receptors with baclofen into the lateral parabrachial nucleus (LPBN) induces ingestion of water and 0.3 M NaCl in fluid replete rats. However, up to now, no study has investigated the effects of baclofen injected alone or combined with GABAB receptor antagonist into the LPBN on water and 0.3 M NaCl intake in rats with increased plasma osmolarity (rats treated with an intragastric...
Inhibition of central angiotensin II-induced pressor responses by hydrogen pero...
Lauar, M. R.; Colombari, Débora Simões de Almeida; Paula, Patricia Maria de; Colombari, Eduardo; Cardoso, Leonardo Máximo; Luca Junior, L. A. deHydrogen peroxide (H2O2), important reactive oxygen species produced endogenously, may have different physiological actions. The superoxide anion (O2 •_) is suggested to be part of the signaling mechanisms activated by angiotensin II (ANG II) and central virus-mediated overexpression of the enzyme superoxide dismutase (that dismutates O2 •_ to H2O2) reduces pressor and dipsogenic responses to central ANG II. Wh...
Cardiovascular responses produced by central injection of hydrogen peroxide in ...
Cardoso, Leonardo Máximo; Colombari, Débora Simões de Almeida; Menani, José Vanderlei; Chianca Júnior, Deoclécio Alves; Colombari, EduardoReactive oxygen species (ROS) have been shown to modulate neuronal synaptic transmission and may play a role on the autonomic control of the cardiovascular system. In this study we investigated the effects produced by hydrogen peroxide (H2O2) injected alone or combined with the anti-oxidant agent N-acetil-l-cysteine (NAC) or catalase into the fourth brain ventricle (4th V) on mean arterial pressure and heart ra...
GABAergic mechanisms of the lateral parabrachial nucleus on sodium appetite.
Oliveira, Lisandra Brandino de; Callera, João Carlos; Luca Junior, L. A. de; Colombari, Débora Simões de Almeida; Menani, José VanderleiGABAergic activation in the lateral parabrachial nucleus (LPBN) induces sodium and water intake in satiated and normovolemic rats. In the present study we investigated the effects of GABAA receptor activation in the LPBN on 0.3M NaCl, water, 2% sucrose and food intake in rats submitted to sodium depletion (treatment with the diuretic furosemide subcutaneously + sodium deficient food for 24 h), 24 h food depriva...
Cardiovascular responses to hydrogen peroxide into the nucleus tractus solitarius.
Cardoso, Leonardo Máximo; Colombari, Débora Simões de Almeida; Menani, José Vanderlei; Toney, Glenn M.; Chianca Júnior, Deoclécio AlvesThe nucleus tractus solitarius (NTS), a major hindbrain area involved in cardiovascular regulation, receives primary afferent fibers from peripheral baroreceptors and chemoreceptors. Hydrogen peroxide (H(2)O(2)) is a relatively stable and diffusible reactive oxygen species (ROS), which acting centrally, may affect neural mechanisms. In the present study, we investigated effects of H(2)O(2) alone or combined wit...