This project was supported by Fundacao para a Ciencia e Tecnologia (FCT grant PIC/IC/82760/2007). RP is supported by a PhD fellowship from FCT (SFRH/BD/80884/2011). TFO was supported by an EMBO Installation Grant, and is currently supported by the DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain, and by a Grant from Parkinson Fonds, Germany. The research leading to these results has rec...
Background: Schistosomiasis is a neglected disease caused by a trematode of the genus Schistosoma that is second only to malaria in public health significance in Africa, South America, and Asia. Praziquantel (PZQ) is the drug of choice to treat this disease due to its high cure rates and no significant side effects. However, in the last years increasingly cases of tolerance to PZQ have been reported, which has ...