5 documents found, page 1 of 1
Co-assembled and microfabricated bioactive membranes
Mendes, A. C.; Smith, K. H.; Tejeda-Montes, E.; Engel, E.; Reis, R. L.; Azevedo, Helena S.; Mata, A.The fabrication of hierarchical and bioactive self-supporting membranes, which integrate physical and biomolecular elements, using a single-step process that combines molecular self-assembly with soft lithography is reported. A positively charged multidomain peptide (with or without the cell-adhesive sequence arginine-glycine-aspartic acid-serine (RGDS)) self-assembles with hyaluronic acid (HA), an anionic biop...
Self-assembly in nature : using the principles of nature to create complex nano...
Mendes, A. C.; Baran, Erkan Türker; Reis, R. L.; Azevedo, Helena S.Self-assembly is a ubiquitous process in biology where it plays numerous important roles and underlies the formation of a wide variety of complex biological structures. Over the past two decades, materials scientists have aspired to exploit nature’s assembly principles to create artificial materials, with hierarchical structures and tailored properties, for the fabrication of functional devices. Toward this goa...
Fabrication of phospholipid–xanthan microcapsules by combining microfluidics wi...
Mendes, A. C.; Baran, Erkan Türker; Reis, R. L.; Azevedo, Helena S.We report the synthesis of an amphiphilic polysaccharide, a phospholipid (1,2-dioleoyl-sn-glycerophosphoetilamine, DOPE) conjugated with the anionic xanthan gum, and its ability to spontaneously self-assemble under mild aqueous conditions. This work also aimed to apply a microfluidic platform that can precisely fabricate microsized and monodispersed capsules for cell encapsulation. Stable hollow capsular struct...
Development of chondroid tissues in lordotic-kyphotic Senegalese sole (Solea se...
Cardeira Da Silva, João; Mendes, A. C.; Pousão-Ferreira, P.; Cancela, Leonor; Gavaia, Paulo J.Vertebral deformities are frequent and constitute a major drawback for many aquaculture produced species. Lordosis and kyphosis, which are severe curvatures of the vertebral column, are particularly problematic, compromising fish marketing and profitability. Senegalese sole is a species with increasing interest in this industry and, like many others, presents high frequencies of vertebral deformities under rear...
New hydrophilic, partially degradable and bioactive cements (HDBC) to improve i...
Mendes, A. C.; Boesel, L. F.; Reis, R. L.[Excerpt] Acrylic bone cements aim to fix prosthesis to bone during hip arthroplasty. The commercial acrylic bone cements perform their function, however at the long term they fail due to aseptic loosening of two interfaces: prosthesis-cement and cement bone. To minimize these problems, the bone growth should be promoted on the surface and inside of the partially degradable bone cement. In our work five differe...