5 documents found, page 1 of 1
Chaves thermal spring water impact on skin health: potential cosmetic application
Pinto-Ribeiro, Inês; Castro, Cláudia; Rocha, Pedro Emanuel; Carvalho, Maria João; Pintado, Ana; Mendes, Adélia; Pedrosa, Sílvia Santos; Capeto, PaulaSince ancient times, thermal spring water has been proven to be beneficial to the skin and to improving dermatologic disorders, explaining its incorporation into cosmetic formulations as an active ingredient. Chaves thermal spring water, from northern Portugal, has been used as a local spa since Roman times, and its customers are satisfied with its medicinal quality. Despite the lack of published evidence on it...
Exploring cannabidiol (CBD) and cannabigerol (CBG) safety profile and skincare ...
Luz-Veiga, Mariana; Mendes, Adélia; Tavares-Valente, Diana; Amorim, Manuela; Conde, António; Pintado, Manuela Estevez; Moreira, Helena R.Cannabinoids have long been known for their bioactive properties, with their topical application as anti-inflammatory compounds being at the forefront of research for the past decade. Concurrently, the cosmetic market is a fast-growing industry in constant need of new biomolecules. In this work, we studied the safety profile for topical applications of two cannabinoids: cannabidiol (CBD) and cannabigerol (CBG) ...
Anti-aging potential of a novel ingredient derived from sugarcane straw extract...
Carvalho, Maria João; Pedrosa, Sílvia Santos; Mendes, Adélia; Azevedo-Silva, João; Fernandes, João; Pintado, Manuela; Oliveira, Ana L. S.Natural and sustainable anti-aging ingredients have gained attention from the cosmetic industry. This study evaluated the anti-aging potential of a sugarcane straw extract-based (SSE) cosmetic ingredient. First, cytotoxicity tests were assessed in keratinocytes and fibroblast cell lines, and sensitization was carried out through the direct peptide reactivity assay. Subsequently, various anti-aging properties we...
From sharks to yeasts: squalene in the development of vaccine adjuvants
Mendes, Adélia; Azevedo-Silva, João; Fernandes, João C.Squalene is a natural linear triterpene that can be found in high amounts in certain fish liver oils, especially from deep-sea sharks, and to a lesser extent in a wide variety of vegeTable oils. It is currently used for numerous vaccine and drug delivery emulsions due to its stability-enhancing properties and biocompatibility. Squalene-based vaccine adjuvants, such as MF59 (Novartis), AS03 (GlaxoSmithKline Biol...
Polymorphisms in the TNFA and IL6 Genes Represent Risk Factors for Autoimmune T...
Durães, Cecília; Moreira, Carla S.; Alvelos, Inês; Mendes, Adélia; Santos, Liliana R.; Machado, José Carlos; Melo, Miguel; Esteves, CésarBackground Autoimmune thyroid disease (AITD) comprises diseases including Hashimoto's thyroiditis and Graves' disease, both characterized by reactivity to autoantigens causing, respectively, inflammatory destruction and autoimmune stimulation of the thyroid-stimulating hormone receptor. AITD is the most common thyroid disease and the leading form of autoimmune disease in women. Cytokines are key regulators of t...