5 documents found, page 1 of 1
Ageing affects the CD4+ T cell polarization and mucosal tropism induced by TLR2...
Zúquete, Sara; Ferreira, Mariana; Delgado, Inês L.; Rosa, Maria teresa; Mendes, Ana Catarina; Santos, Dulce; Nolasco, Sofia; Graça, LuísToll-like receptor (TLR)2 activation induces aldehyde dehydrogenase enzymes in non-mucosal dendritic cells (DCs), enabling them to metabolize vitamin A into all-trans retinoic acid, which induces the expression of mucosal-homing molecules (α4β7 and CCR9) in the activated T cells. Recently, we have shown that the simultaneous activation of non-mucosal DCs through TLR2 and TLR4 maintains such capacity while reinf...
Combined TLR2/TLR4 activation equip non-mucosal dendritic cells to prime Th1 ce...
Zúquete, Sara; Ferreira, Mariana; Delgado, Inês L. S.; Gazalle, Paula; Andaluz, Stephanie; Rosa, Maria Teresa; Mendes, Ana Catarina; Santos, DulceActivated CD4+ T cells located at mucosal surfaces orchestrate local effector immune mechanisms. When properly polarized, these cells contribute to block infections at early stages and may be essential to restrain the local growth of mucosal tumors, playing a critical role in host protection. How CD4+ T cells simultaneously integrate gut-homing instructions and Th polarization signals transmitted by TLR-activat...
Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence ...
Pedroso, Rodrigo B.; Torres, Lícia; Ventura, Lucas Araújo; Camatta, Giovanna Caliman; Mota, Catarina; Mendes, Ana Catarina; Ribeiro, FilipaRisk factors for the development of severe COVID-19 include several comorbidities, but age was the most striking one since elderly people were disproportionately affected by SARS-CoV-2 infection. Among the reasons for this markedly unfavorable response in the elderly, immunosenescence and inflammaging appear as major drivers of this outcome. A finding that was also notable was that hospitalized patients with se...
Key performance indicators: a perspective on developing and implementing perfor...
Costa, Ana Francisca; Pinto, Ana; Mendes, Ana Catarina; Quinteiro, Ana Rita; Coelho, Carla; Meira, Carla; Pereira, Isac; Marinho, Jorge; Barbosa, JoséThe performance of a company’s warehouse influences its competitiveness. High-performance warehouse management allows the company to increase profit, reduce delivery time and provide better customer service. To have a perception of the warehouse management performance, it is necessary to identify the Key Performance Indicators (KPI) and be able to monitor them. Creating a performance monitoring system in an ind...
Peregrinos a Santiago de Compostela:uma etnografia do caminho português
Mendes, Ana CatarinaEsta dissertação de mestrado tem como tema as peregrinações no Caminho deSantiago. O universo em estudo é o dos peregrinos que percorrem o Caminho Portuguêsde Santiago de Compostela. A problemática central prende-se com as motivações e osobjectivos dos peregrinos, tendo em atenção as razões que os levam a percorrer oCaminho de Santiago a pé. A dissertação está dividida em três partes: EnquadramentoHistórico, Tr...