7 documents found, page 1 of 1
Preclinical assessment of an antibiotic-free cationic surfactant-based cellulos...
Calado, Rita D.A.; Mendes, Bárbara B.; Conniot, João; Ravasco, João M.J.M.; Sobral, Daniel; Ferreira, Carolina; Ferreira, Rita; Rodrigues, João CarlosSexually transmitted infections and urogenital-perinatal infections are significant health challenges owing to their asymptomatic nature, multidrug-resistant pathogens, and lack of effective vaccines. Surfactants are under investigation as potential antimicrobial agents and alternatives to traditional antibiotics. Here, we discovered that N-dodecylpyridinium bromide (C12PB), a cationic quaternary ammonium surfa...
Injectable hyaluronic acid and platelet lysate-derived granular hydrogels for b...
Mendes, Bárbara B.; Daly, Andrew C.; Reis, R. L.; Domingues, Rui Miguel Andrade; Gomes, Manuela E.; Burdick, Jason A.Towards the repair of damaged tissues, numerous scaffolds have been fabricated to recreate the complex extracellular matrix (ECM) environment to support desired cell behaviors; however, it is often challenging to design scaffolds with the requisite cell-anchorage sites, mechanical stability, and tailorable physicochemical properties necessary for many applications. To address this and to improve on the properti...
Human platelet lysate-based nanocomposite bioink for bioprinting hierarchical f...
Mendes, Bárbara B.; Gómez-Florit, M.; Hamilton, Alex G.; Detamore, Michael S.; Domingues, Rui Miguel Andrade; Reis, R. L.; Gomes, Manuela E.Three-dimensional (3D) bioprinting holds the promise to fabricate tissue and organ substitutes for regenerative medicine. However, the lack of bioactive inks to fabricate and support functional living constructs is one of the main limitations hindering the progress of this technology. In this study, a biofunctional human-based nanocomposite bioink (HUink) composed of platelet lysate hydrogels reinforced by cell...
Natural materials
Gomez-Florit, Manuel; Domingues, Rui Miguel Andrade; Bakht, Syeda Mahwish; Mendes, Bárbara B.; Reis, R. L.; Gomes, Manuela E.The use of naturally occurring materials as scaffolds to support cell growth and proliferation significantly impacted the origin and progress of tissue engineering and regenerative medicine. However, the majority of these materials failed to provide adequate cues to guide cell differentiation toward the formation of new tissues. Over the past decade, a new generation of multifunctional and smart natural-based m...
Injectable and magnetic responsive hydrogels with bioinspired ordered structures
Araújo-Custódio, Sandra; Gomez-Florit, Manuel; Tomás, Ana R.; Mendes, Bárbara B.; Babo, Pedro Miguel Sousa; Mithieux, Suzanne M; Weiss, AnthonyInjectable hydrogels are particularly interesting for applications in minimally invasive tissue engineering and regenerative medicine strategies. However, the typical isotropic microstructure of these biomaterials limits their potential for the regeneration of ordered tissues. In the present work, we decorated rod-shaped cellulose nanocrystals with magnetic nanoparticles and coated these with polydopamine and p...
Human-based nanocomposite cryogels for hemostatic and wound healing applications
Mendes, Bárbara B.; Gomez-Florit, Manuel; Randall, Lindsey; Babo, Pedro Miguel Sousa; Almeida, Raquel Carvalho Ferreira Costa; Detamore, Michael S.In trauma surgery, a fast and effective hemostatic agent is crucial to prevent death. The current used hemostatic sponges are highly effective in stopping the hemorrhages, however they have a limited stability, shape memory, and biological functionality to induce an efficient regenerative healing after injury. Blood derivatives have attracted great attention as an inexpensive milieu of bioactive molecules (e.g....
Engineering magnetically responsive tropoelastin spongy-like hydrogels for soft...
Pesqueira, Tamagno; Almeida, Raquel Carvalho Ferreira Costa; Mithieux, Suzanne M.; Babo, Pedro Miguel Sousa; Franco, Albina Ribeiro; Mendes, Bárbara B.Magnetic biomaterials are a key focus in medical research. Tropoelastin is the soluble precursor of elastin and is a critical component of tissues requiring elasticity as part of their physiological function. By utilising the versatility of tropoelastin and the ability to tailor its properties, we developed a novel magnetic spongy-like hydrogel based on tropoelastin doped with magnetic properties by in situ pre...