13 documents found, page 1 of 2
Practical Guidance on the Detection of NTRK Fusions in Sarcomas: Current Status...
Fernandes, I; Macedo, D; Gouveia, E; Ferreira, A; Lima, J; Lopez, D; Melo-Alvim, C; Carvalho, A; Tavares, P; Rodrigues-Santos, P; Cardoso, PSarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed novel and unexpected therapeutic targets with prognostic/pr...
The Cardiometabolic Impact of Rebaudioside A Exposure during the Reproductive S...
Bracchi, I; Morais, J; Coelho, JA; Ferreira, AF; Alves, I; Mendes, C; Correia, B; Gonçalves, A; Guimarães, JT; Pires, IF; Keating, E; Negrão, RThe consumption of non-sugar sweeteners (NSS) has increased during pregnancy. The European Food Safety Agency suggested that steviol glycosides, such as Rebaudioside A (RebA), the major sweetener component of stevia, are safe for humans up to a dose of 4 mg/kg body weight/day. However, the World Health Organization recommended in 2023 the restraint of using NSS, including stevia, at any life stage, highlighting...
Lower prevalence of congenital cytomegalovirus infection in Portugal: possible ...
Fernandez, C; Chasqueira, MJ; Marques, A; Rodrigues, L; Marçal, M; Tuna, M; Braz, MC; Neto, AS; Mendes, C; Lito, D; Rocha, P; Vasconcellos, GCytomegalovirus (CMV) is the most frequent cause of congenital infection all over the world. Its prevalence ranges from 0.2 to 2.2%. Transmission from children to their pregnant mothers is a well-known risk factor, particularly if they attend a childcare centre. This study aims to compare the prevalence of CMV congenital infection (CMV_CI) in Portugal (Lisbon) between two studies, performed respectively in 2019...
Perivascular Epithelioid Cell Tumor: A Case Report of a Rare Entity
Cardosa, MF; Ferreira de Lima, S; Knoblich, M; Afonso, I; Mendes, CPerivascular epithelioid cell tumor is a rare mesenchymal tumor with myomelanocytic differentiation. It mainly occurs in middle-aged females and can be found at any location. The differential diagnosis is broad but the immunohistochemical biomarkers establish the diagnosis. A 4-year-old girl was referred to a pediatric gastroenterology clinic due to recurrent umbilical pain and the workup revealed biliary lithi...
Atrial matrix remodeling in atrial fibrillation patients with aortic stenosis
Fragão-Marques, M; Miranda, I; Martins, D; Barroso, I; Mendes, C; Pereira-Neves, A; Falcão-Pires, I; Leite-Moreira, ABackground. This study aimed to evaluate atrium extracellular matrix remodeling in atrial fibrillation (AF) patients with severe aortic stenosis, through histological fibrosis quantification and extracellular matrix gene expression analysis, as well as serum quantification of selected protein targets. Methods. A posthoc analysis of a prospective study was performed in a cohort of aortic stenosis patients. Betwe...
Identification of a novel deletion in SURF1 gene: Heterogeneity in Leigh syndro...
Ribeiro, C; Macário, MC; Viegas, AT; Pratas, J; Santos, MJ; Simões, M; Mendes, C; Bacalhau, M; Garcia, P; Diogo, L; Grazina, MLeigh syndrome (LS) is a rare, progressive neurodegenerative mitochondrial disorder of infancy. It is a genetically heterogeneous disease. The mutations in SURF1 gene are the most frequently known cause. Here two cases of LS likely caused by SURF1 gene variants are reported: a 39-year-old male patient with a novel homozygous deletion (c.-11_13del), and a case of a 6-year-old boy with the same deletion and a non...
Validation of control of allergic rhinitis and asthma test for children (CARATK...
Linhares, DV; Fonseca, JA; Borrego, LM; Matos, A; Pereira, AM; Sá-Sousa, A; Gaspar, A; Mendes, C; Moreira, C; Gomes, E; Rebelo, FFBACKGROUND: Control of Allergic Rhinitis and Asthma Test for Children (CARATKids) is the first questionnaire that assesses simultaneously allergic rhinitis and asthma control in children. It was recently developed, but redundancy of questions and its psychometric properties were not assessed. This study aimed to (i) establish the final version of the CARATKids questionnaire and (ii) evaluate its reliability, re...
STOP Quedas: Programa de Gestão e Controlo das Quedas de Doentes em Ambiente Ho...
Ramos, S; Fragata, J; Barata, F; Bordalo, I; Lage, J; Marinho, A; Mendes, C; Paes Duarte, A; Tavares, L; Timóteo, AT; Trindade, LAs quedas têm um impacto na morbilidade e na qualidade de vida do doente, contribuindo para o aumento dos custos dos cuidados de saúde. Dos múltiplos fatores que podem contribuir para as quedas, destaca-se a idade (acima dos 65 anos), o estado mental, a medicação que o doente está a tomar, história de queda anterior e fatores ambientais. O Centro Hospitalar de Lisboa Central no âmbito da Gestão do Risco monitor...
Novas vacinas
Ferreira, M; Leal, E; Galhardo, J; Mendes, C; Soares, H; Brito, MJIntrodução: As vacinas previnem mais casos de doença do que qualquer tratamento médico. A informação sobre novas vacinas introduzidas no mercado e não incluídas no Programa Nacional de Vacinação (PNV) é no entanto por vezes pouco divulgada, e o seu conhecimento limitado. Objectivos: Avaliar o conhecimento, geral e específico, dos pais de crianças saudáveis relativamente a três vacinas não incluídas no PNV: pneu...
Novas Vacinas
Ferreira, M; Leal, E; Galhardo, J; Mendes, C; Soares, H; Brito, MJIntrodução: As vacinas previnem mais casos de doença do que qualquer tratamento médico. A informação sobre novas vacinas introduzidas no mercado e não incluídas no Programa Nacional de Vacinação (PNV) é no entanto por vezes pouco divulgada, e o seu conhecimento limitado. Objectivos: Avaliar o conhecimento, geral e específico, dos pais de crianças saudáveis relativamente a três vacinas não incluídas no PNV: pneu...