6 documents found, page 1 of 1
Lower prevalence of congenital cytomegalovirus infection in Portugal: possible ...
Fernandez, Catarina; Chasqueira, Maria-Jesus; Marques, Augusta; Rodrigues, Lúcia; Marçal, Mónica; Tuna, Madalena; Braz, Mónica Cró; Neto, Ana Serrão
Vegetação dos Açores
Dias, Eduardo; Mendes, Cândida; Aguiar, CarlosEste capítulo tem por objeto a paisagem vegetal do arquipélago dos Açores, região biogeográfica da Macaronésia. Situado no oceano Atlântico, entre a Europa e América do Norte, o arquipélago dos Açores é formado por nove ilhas e alguns ilhéus, comportando uma biodiversidade florística e faunística com elevado interesse do ponto de vista biológico, ecológico e científico, bem como numa perspetiva socioeconómica e...
Metabolic effects of hypoxia in colorectal cancer by 13C NMR isotopomer analysis
Abrantes, Ana M.; Tavares, Ludgero C.; Pires, Salomé; Casalta-Lopes, João; Mendes, Cândida; Simões, Marta; Grazina, Manuela M.; Carvalho, Rui A.(13)C NMR isotopomer analysis was used to characterize intermediary metabolism in three colorectal cancer cell lines (WiDr, LS1034, and C2BBe1) and determine the "metabolic remodeling" that occurs under hypoxia. Under normoxia, the three colorectal cancer cell lines present high rates of lactate production and can be seen as "Warburg" like cancer cells independently of substrate availability, since such profile...
Validation of control of allergic rhinitis and asthma test for children (CARATK...
Linhares, Daniela V. B. R.; Fonseca, João Almeida L. da; Borrego, Luís Miguel; Matos, Águeda; Pereira, Ana Margarida; Sousa, Ana Sá; Gaspar, ÂngelaBACKGROUND: Control of Allergic Rhinitis and Asthma Test for Children (CARATKids) is the first questionnaire that assesses simultaneously allergic rhinitis and asthma control in children. It was recently developed, but redundancy of questions and its psychometric properties were not assessed. This study aimed to (i) establish the final version of the CARATKids questionnaire and (ii) evaluate its reliability, re...
Coenzyme Q10 deficiency in mitochondrial DNA depletion syndromes
Montero, Raquel; Grazina, Manuela; López-Gallardo, Ester; Montoya, Julio; Briones, Paz; Navarro-Sastre, Aleix; Land, John M.; Hargreaves, Iain P.We evaluated coenzyme Q10 (CoQ) levels in patients studied under suspicion of mitochondrial DNA depletion syndromes (MDS) (n = 39). CoQ levels were quantified by HPLC, and the percentage of mtDNA depletion by quantitative real-time PCR. A high percentage of MDS patients presented with CoQ deficiency as compared to other mitochondrial patients (Mann–Whitney-U test: p = 0.001). Our findings suggest that MDS are f...
Frontotemporal dementia and mitochondrial DNA transitions
Grazina, Manuela; Silva, Filipe; Santana, Isabel; Santiago, Beatriz; Mendes, Cândida; Simões, Marta; Oliveira, Miguel; Cunha, Luís; Oliveira, CatarinaFrontotemporal dementia (FTD) is the second most common type of primary degenerative dementia. Some patients present an overlap between Alzheimer's disease (AD) and FTD both in neuropathological and clinical aspects. This may suggest a similar overlap in physiopathology, namely an involvement of mitochondrial DNA (mtDNA) in FTD, as it has been associated to AD. To determine if mtDNA is involved in FTD, we perfo...