9 documents found, page 1 of 1
Practical Guidance on the Detection of NTRK Fusions in Sarcomas: Current Status...
Fernandes, Isabel; Macedo, Daniela; Gouveia, Emanuel; Ferreira, Ana; Lima, Jorge; Lopez, Dolores; Melo-Alvim, Cecília; Carvalho, Alice; Tavares, PauloSarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed novel and unexpected therapeutic targets with prognostic/pr...
Design e artesanato 20 verbos - 20 cartazes
Albino, Cláudia (coord.); Paoliello, Carla (coord.); Borges, Adélia; Bandoni, Andrea; Paes, Bete; Mendes, Cristina; Martins, FernandaSem resumo disponível.
Perivascular Epithelioid Cell Tumor: A Case Report of a Rare Entity
Cardosa, Maria Filomena; Ferreira de Lima, Sofia; Knoblich, Maria; Afonso, Isabel; Mendes, CristinaPerivascular epithelioid cell tumor is a rare mesenchymal tumor with myomelanocytic differentiation. It mainly occurs in middle-aged females and can be found at any location. The differential diagnosis is fairly broad but the immunohistochemical biomarkers establish the diagnosis. Afour-year-old girl was referred to pediatric gastroenterology consultation due to recurrent umbilical pain and the workup revealed ...
Plasmodium falciparum Genetic Diversity in Continental Equatorial Guinea before...
Guerra, Mónica; Neres, Rita; Salgueiro, Patrícia; Mendes, Cristina; Ndong-Mabale, Nicolas; Berzosa, Pedro; Sousa, Bruno de; Arez, Ana PaulaEfforts to control malaria may affect malaria parasite genetic variability and drug resistance, the latter of which is associated with genetic events that promote mechanisms to escape drug action. The worldwide spread of drug resistance has been a major obstacle to controlling Plasmodium falciparum malaria, and thus the study of the origin and spread of associated mutations may provide some insights into the pr...
Characterization of rotavirus infection in children with acute gastroenteritis ...
Gasparinho, Carolina; Piedade, João; Mirante, Maria Clara; Mendes, Cristina; Mayer, Carlos; Nery, Susana Vaz; Brito, Miguel; Istrate, ClaudiaRotavirus group A (RVA) is considered the leading cause of pediatric diarrhea, responsible for the high burden of diarrheal diseases in sub-Saharan Africa. Despite recent studies, the existent data are scarce for some African countries like Angola, a country with one of the highest RVA-related death estimates. The aim of this study was to determine the RVA detection rate and circulating genotypes in children le...
Factores de risco para complicações e sequelas de meningites bacterianas
Ferreira, Marta; Mendes, Cristina; Janeiro, Patrícia; Conde, Marta; Aguiar, Teresa; João Brito, MariaIntrodução: A meningite bacteriana é uma infecção potencial mente grave, associada a complicações e sequelas a longo prazo. Objectivo: Caracterizar a meningite bacteriana em doentes internados num Hospital Geral, na Zona Metropolitana de Lisboa, e avaliar eventuais factores de risco para o prognóstico. Métodos: Revisão casuística, entre Junho de 1996 e Dezembro de 2005. Realizou-se análise descritiva dos dados ...
Genetic diversity and signatures of selection of drug resistance in Plasmodium ...
Mendes, Cristina; Salgueiro, Patrícia; Gonzalez, Vicenta; Berzosa, Pedro; Benito, Agustin; Rosário, Virgílio E. do; Sousa, Bruno de; Cano, JorgeIn Plasmodium, the high level of genetic diversity and the interactions established by co-infecting parasite populations within the same host may be a source of selection on pathogen virulence and drug resistance. As different patterns have already been described in humans and mosquitoes, parasite diversity and population structure should be studied in both hosts to properly assess their effects on infection an...
Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly fr...
Machado, Patrícia; Manco, Licínio; Gomes, Cláudia; Mendes, Cristina; Fernandes, Natércia; Salomé, Graça; Sitoe, Luis; Chibute, Sérgio; Langa, JoséBackground: Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far. This work shows the results of a study undertaken to determine PK deficiency occurrence in some sub-Saharan African countries, as well as finding a prevalent PK variant underlying this deficiency. Materials and Methods: Blood samples of in...
New vaccines.
Ferreira, Marta; Leal, Ema; Galhardo, Júlia; Mendes, Cristina; Soares, Henrique; Brito, Maria JoãoVaccines prevent more cases of diseases than any other medical treatment. However, information on new vaccines introduced in the market and not included in the National Vaccination Program (NVP) is often sparse, and their knowledge limited.Evaluate general and specific knowledge of healthy children's parents on three vaccines not included in the NVP: pneumococcal (PCV7), varicella (Var) and rotavirus (RV).Trans...