7 documents found, page 1 of 1

Preclinical validation of a new hybrid molecule loaded in liposomes for melanom...

The aggressiveness of melanoma and lack of effective therapies incite the discovery of novel strategies. Recently, a new dual acting hybrid molecule (HM), combining a triazene and a ʟ-tyrosine analogue, was synthesized. HM was designed to specifically be activated by tyrosinase, the enzyme involved in melanin biosynthesis and overexpressed in melanoma. HM displayed remarkable superior antiproliferative activity...

Selenium and redox enzyme activity in pregnant women exposed to methylmercury

Selenium (Se) is a micronutrient with essential physiological functions achieved through the production of selenoproteins. Adequate Se intake has health benefits and reduces mercury (Hg) toxicity, which is important due to its neurotoxicity. This study determined the Se status and redox enzyme, including selenoproteins’, activity in pregnant women highly exposed to Hg (between 1 to 54 µg Hg/L blood) via fish co...

The role of technologies in relationship management and internal marketing: an ...

In health, as in any other industry, technology adoption, if used appropriately, is an important asset and a success factor for a company. Nowadays, it is no longer feasible to talk about health without addressing the role of technology. In this context, the present study aims to understand the impact and role of technologies in a hospital context (e.g., Hospital de Braga), and in the relationship management fr...

Dopamine- and tyramine-based derivatives of triazenes

A range of triazene derivatives were synthesized and investigated as prodrug candidates for melanocyte-directed enzyme prodrug therapy (MDEPT). The prodrugs contained a tyramine or dopamine promoiety required for tyrosinase activation and this was joined via a urea functional group to the cytotoxic triazene. The stability of each of the prodrugs in phosphate buffer, human plasma and in mushroom tyrosinase is di...

Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac

Aminocarbonyloxymethyl ester prodrugs are known to undergo rearrangement in aqueous solutions to form the corresponding N-acylamine side product via an 0 - N intramolecular acyl transfer from the carbamate conjugate base. Novel aminocarbonyloxymethyl esters of diclofenac and flufenamic acid containing amino acid amide carriers were synthesized and evaluated as potential prodrugs displaying less ability to under...

Synthesis and Evaluation of triazene prodrugs as candidate for Melanocyte-Direc...

Potenciais Pró-Fármacos do Ácido Flufenâmico