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The Acute Effects of a Fast-Food Meal Versus a Mediterranean Food Meal on the A...
Silva, D; Mendes, FC; Stanzani, V; Moreira, R; Pinto, M; Beltrão, M; Sokhatska, O; Severo, M; Padrão, P; Garcia-Larsen, V; Delgado, L; Moreira, ABackground/Objectives: This study aimed to assess the acute effects of two isoenergetic but micronutrient-diverse meals—a Mediterranean-like meal (MdM) and a fast food-like meal (FFM)—on the autonomic nervous system (ANS), lung function, and airway inflammation response. Methods: Forty-six participants were enrolled in a randomized crossover clinical trial, consuming two isoenergetic meals: FFM (burger, fries, ...
Skin barrier dysfunction associates with type 2 inflammatory diseases: Evidence...
Abreu, DB; Mendes, FC; Silva, D; Barros, H; Moreira, A
Component-resolved diagnosis in childhood and prediction of asthma in early ado...
Farraia, M; Mendes, FC; Sokhatska, O; Rama, T; Severo, M; Custovic, A; Cavaleiro Rufo, J; Barros, H; Moreira, A"Introduction Component-resolved diagnosis (CRD) has been decisive in exploring the mechanisms of IgE sensitization, but the predictive ability to detect asthma has not been addressed. We aim to develop and evaluate the performance of a personalized predictive algorithm for asthma that integrates information on allergic sensitization using CRD. Methods One thousand one hundred one twenty-five children from the ...
Cost-effectiveness analysis of grass pollen specific immunotherapy in children ...
Farraia, M; Paciência, I; Mendes, FC; Cavaleiro Rufo, J; Delgado, L; Moreira, ABackground. Cost-effectiveness studies evaluating allergen immunothera-py (AIT) in children are scarce. We aim to compare the cost-effectiveness of subcutaneous (SCIT) and sublingual immunotherapy (SLIT) against stan-dard-of-care (SOC) treatment in children with grass pollen allergic rhinitis. Methods. We created a Markov model to compare the three strategies over a 10-year horizon. SOC was the reference to cal...
Sensitization trajectories to multiple allergen components in a population-base...
Farraia, M; Mendes, FC; Sokhatska, O; Severo, M; Cavaleiro Rufo, J; Barros, H; Moreira, ABackgroundThe characteristics of allergic sensitization profiles can differ between populations and geographic regions, contributing differently to the association with allergic diseases. Consequently, the sensitization trajectories found in previous studies conducted in Northern Europe may not apply in Southern European countries. ObjectiveTo identify trajectories of allergic sensitization profiles during chil...
Dietary Acid Load Modulation of Asthma-Related miRNAs in the Exhaled Breath Con...
Mendes, FC; Paciencia, I; Rufo, JC; Silva, D; Delgado, L; Moreira, André; Moreira, PedroIndividual nutrients and bioactive compounds have been implicated in the expression of microRNAs (miRNAs), which are related to inflammation and asthma. However, evidence about the impact of diet is scarce. Therefore, we aimed to assess the association between dietary acid load and asthma-related miRNA in the exhaled breath condensate (EBC) of school-aged children. This cross-sectional analysis included 150 par...
Association between Elevated Iodine Intake and IQ among School Children in Port...
Carvalho, IP; Peixoto, B; Caldas, JC; Costa, A; Silva, S; Moreira, B; Almeida, A; Moreira-Rosário, A; Guerra, A; Delerue-Matos, C; Sintra, D; Pestana, DThe goal of this work was to examine whether elevated iodine intake was associated with adverse effects on IQ among school-age children in Portugal. In a representative sample of children from the north of the country, IQ percentiles by age (assessed with Raven’s Colored Progressive Matrices) were dichotomized to <50 (“below-average” IQs) and ≥50. Morning urine iodine concentrations, corrected for creatinine, w...
Bronchodilator responsiveness in healthy children: Insights from a cross-sectio...
Tiago Rama; Martins, C; Paciencia, I; Rufo, J; Silva, D; Mendes, FC; Severo, M; Padrão, Patrícia; Moreira, Pedro; Delgado, L; Moreira, A
Exhaled breath condensate volatilome allows sensitive diagnosis of persistent a...
Cavaleiro Rufo, J; Paciência, I; Mendes, FC; Farraia, M; Rodolfo, A; Silva, D; de Oliveira Fernandes, E; Delgado, L; Moreira, ABackground The diagnosis and phenotyping of paediatric asthma are particularly complex due to the lack of currently available sensitive diagnostic tools. This often results in uncertainties associated with inhaled steroid therapy prescription. Therefore, this study aimed to investigate whether volatile organic compounds measured in exhaled breath condensate can be used as biomarkers for asthma diagnosis in the ...
Development and validation of exhaled breath condensate microRNAs to identify a...
Mendes, FC; Paciência, I; Ferreira, AC; Martins, C; Rufo, JC; Silva, D; Cunha, P; Farraia, M; Moreira, P; Delgado, L; Soares, ML; Moreira, ADetection and quantification of microRNAs (miRNAs) in exhaled breath condensate (EBC) has been poorly explored. Therefore we aimed to assess miRNAs in EBC as potential biomarkers to diagnose and endotype asthma in school aged children. In a cross sectional, nested case control study, all the asthmatic children (n = 71) and a random sample of controls (n = 115), aged 7 to 12 years, attending 71 classrooms from 2...