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Optimizing levodopa therapy, when and how? Perspectives on the importance of de...

Lees, Andrew; Tolosa, Eduardo; Stocchi, Fabrizio; Ferreira, Joaquim J; Rascol, Olivier; Antonini, Angelo; Poewe, Werner

Introduction: There is currently a resurgence of levodopa as the initial treatment of choice for most patients with Parkinson's disease, albeit at lower doses than previously used. The addition of adjuvant treatments (including MAO-B inhibitors, COMT inhibitors and dopamine agonists) is an established strategy to reduce motor complications that develop with sustained levodopa therapy. Areas covered: In this nar...


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