37 documents found, page 1 of 4

Novel yeast-based biosensor for environmental monitoring of tebuconazole

Abstract: Due to increasing demand for high and stable crop production, human populations are highly dependent on pesticide use for growing and storing food. Environmental monitoring of these agrochemicals is therefore of utmost importance, because of their collateral effects on ecosystem and human health. Even though most current-use analytical methods achieve low detection limits, they require procedures that...

Chronic Kidney Disease: Supportive and Conservative Care in Portugal in 2023

Introduction: Elderly patients with chronic kidney disease (CKD) present a higher risk of becoming frail, a consequence of several comorbidities and worse functional status. This condition does not necessarily improve with the initiation of dialysis. Conservative care offers an option to treat elderly and/or frail patients with advanced CKD, which focuses on improving the patient’s quality of life, active sympt...

A versatile yeast model identifies the pesticides cymoxanil and metalaxyl as ri...

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of Lewy bodies, which predominantly consist of aggregated forms of the protein alpha-synuclein (aSyn). While these aggregates are a pathological hallmark of PD, the etiology of most cases remains elusive. Although environmental risk factors have been identified, such as the pesticides diel...

Cymoxanil inhibits respiration through inhibition of mitochondrial complex IV

Cymoxanil is a synthetic acetamide fungicide, used against oomycetes. It was first introduced in 1977 and can be used against downy mildew diseases induced by Plasmopara viticola in grapevine cultures and late blight diseases caused by Phytophthora infestans, in tomatoes and potatoes cultures. This fungicide is used in mixed formulations and its higher solubility enables a relatively widespread occurrence in to...

The logical essence of compiling with continuations

The essence of compiling with continuations is that conversion to continuation-passing style (CPS) is equivalent to a source language transformation converting to administrative normal form (ANF). Taking as source language Moggi's computational lambda-calculus (lambdaC), we define an alternative to the CPS-translation with target in the sequent calculus LJQ, named value-filling style (VFS) translation, and maki...

Lifestyle changes appointment in primary health care setting

Obesity is an increasing public health issue around the world. Lifestyle counselling is one of the core competencies of family doctors and can contribute to the prevention, control, and counteract of chronic disease complications. The paucity of resources in primary care practices makes an adequate response challenging. Therefore, a group of health professionals from a primary care public Family Health Unit man...

The Mössbauer effect using 57Fe-ferrabisdicarbollide ([o-57FESAN]−) : a glance ...

Although a variety of cancers are initially susceptible to chemotherapy, they eventually develop multi-drug resistance. To overcome this situation, more effective and selective treatments are necessary using anti-tumour agents that act in two or more ways and offer greater therapeutic benefits over single-mechanism entities. In this study, we report on treating cancer with Na[3,3′-57Fe(1,2-C2B9H11)2], which off...

The upsizing of the São Tomé seed dispersal network by introduced animals

The upsizing of the São Tomé seed dispersal network by introduced animals

Biological invasions are a major threat to global biodiversity with particularly deleterious consequences on oceanic islands. The introduction of large terrestrial animals – generally absent on islands – can disrupt important ecosystem functions, such as the dispersal of native seeds. However, while the consequences of plant invasions received much attention, the potential of introduced animals to change insula...

Copper-64 Chloride Exhibits Therapeutic Potential in Three-Dimensional Cellular...

Prostate cancer (PCa) is the second most common cancer type in men, and in advanced metastatic stages is considerable incurable. This justifies the need for efficient early diagnostic methods and novel therapies, particularly radiopharmaceuticals with the potential for simultaneous diagnosis and therapy (theranostics). We have previously demonstrated, using monolayer-cultured cells, that copper-64 chloride, a p...