19 documents found, page 1 of 2
Model-based prototyping of a controller for MR actuators
Mendes, Gabriel; Gołdasz, Janusz; Ferreira, Ângela P.Magnetorheological (MR) actuators are semi-active devices that leverage the smart properties of the MR fluids whose rheology can be controlled by an external magnetic field. Within the presence of an external magnetic field, the magnetic domains of the MR fluid align with the external field, which results in the yield stress induced in the fluid, thus undergoing a transition from a fluid to a semi-solid. Thus, ...
Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
Mendes, Gabriel; Santos, Maria Leonor; Ramalho, João Francisco; Duarte, Aida; Caneiras, CatiaHypervirulence and carbapenem-resistant have emerged as two distinct evolutionary pathotypes of Klebsiella pneumoniae, with both reaching their epidemic success and posing a great threat to public health. However, as the boundaries separating these two pathotypes fade, we assist a worrisome convergence in certain high-risk clones, causing hospital outbreaks and challenging every therapeutic option available. To...
Saúde ambiental : caderno de notas soltas III
Santos, Ricardo; Santos, Osvaldo; Abreu, Ana; Caminha, Luís; Costa, Andreia; Sul, Susana; Nogueira, Paulo Jorge; Henriques, Adriana; Arriaga, MiguelNa sua 3.ª edição, o Caderno de Notas Soltas pretende reunir diferentes perspetivas e metodologias, celebrando a sua razão de ser e a nobreza da sua génese intimamente ligada à realidade dos estudantes. Na verdade, passados três anos retomamos uma colaboração firmada desde a primeira hora com a Associação de Estudantes da Faculdade de Medicina de Lisboa (AEFML), num registo de proximidade da comunidade estudant...
Genomic characterisation of a novel KPC-98-producing clinical Klebsiella pneumo...
Mendes, Gabriel; Santos, Maria Leonor; Ramalho, João Francisco; Bruschy-Fonseca, Ana; Lito, Luís; Pedro, Diogo; Duarte, Aida; Cristino, José MeloCeftazidime/avibactam (CZA) is a novel drug that inactivates Ambler class A, including Klebsiella pneumoniae carbapenemases (KPC), class C and class D β-lactamases, but is not active against metallo-β-lactamases (class B). Despite its limited use worldwide, emerging cases of CZA-resistant isolates producing variants of the blaKPC gene have been reported. In this study, we report a novel KPC-98 variant conferrin...
MAMMALS IN PORTUGAL: A data set of terrestrial, volant, and marine mammal occur...
Grilo, Clara; Afonso, Beatriz C.; Afonso, Filipe; Alexandre, Marta; Aliácar, Sara; Almeida, Ana; Alonso, Ivan Prego; Álvares, Francisco; Alves, PauloMammals are threatened worldwide, with 26% of all species being included in the IUCN threatened categories. This overall pattern is primarily associated with habitat loss or degradation, and human persecution for terrestrial mam mals, and pollution, open net fishing, climate change, and prey depletion for marine mammals. Mammals play a key role in maintaining ecosystems func tionality and resilience, and theref...
First outbreak of NDM-1-producing Klebsiella pneumoniae ST11 in a Portuguese ho...
Mendes, Gabriel; Ramalho, João Francisco; Duarte, Aida; Pedrosa, Adriana; Silva, Ana Cristina; Méndez, Lucía; Caneiras, CatiaNew Delhi metallo-β-lactamase (NDM) carbapenemase has been considered a global threat due to its worldwide widespread in recent years. In Portugal, a very low number of infections with NDM-producing Enterobacterales has been reported. A total of 52 strains from 40 patients and 1 environmental sample isolated during COVID-19 pandemic were included in this study. Wholegenome sequencing (WGS) was performed on 20 c...
First description of Ceftazidime/Avibactam resistance in an ST13 KPC-70-produci...
Mendes, Gabriel; Ramalho, João Francisco; Bruschy-Fonseca, Ana; Lito, Luís; Duarte, Aida; Cristino, José Melo; Caneiras, CatiaThe combination of ceftazidime/avibactam (CZA) is a novel β-lactam/β-lactamase inhibitor with activity against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacterales. Emerging cases caused by CZA-resistant strains that produce variants of KPC genes have already been reported worldwide. However, to the best of our knowledge, no CZA-resistant strains were reported in Portugal. In September 2019, a K...
MAMMALS IN PORTUGAL : A data set of terrestrial, volant, and marine mammal occu...
Grilo, Clara; Afonso, Beatriz C.; Afonso, Filipe; Alexandre, Marta; Aliácar, Sara; Almeida, Ana; Alonso, Ivan Prego; Álvares, Francisco; Alves, PauloMammals are threatened worldwide, with 26% of all species being includedin the IUCN threatened categories. This overall pattern is primarily associatedwith habitat loss or degradation, and human persecution for terrestrial mam-mals, and pollution, open net fishing, climate change, and prey depletion formarine mammals. Mammals play a key role in maintaining ecosystems func-tionality and resilience, and therefore...
Whole-genome sequencing enables molecular characterization of non-clonal group ...
Mendes, Gabriel; Ramalho, João Francisco; Bruschy Fonseca, Ana; Lito, Luís; Duarte, Aida; Cristino, José Melo; Caneiras, CatiaThe carbapenem-resistant Enterobacterales (CRE) strains have been identified by the World Health Organization as critical priority pathogens in research and development of diagnostics, treatments, and vaccines. However, recent molecular information about carbapenem-resistant K. pneumoniae (CRK) epidemiology in Portugal is still scarce. Thus, this study aimed to provide the molecular epidemiology, resistome, and...
KPC-3-producing Klebsiella pneumoniae sequence type 392 from a dog’s clinical i...
Moreira da Silva, Joana; Menezes, Juliana; Mendes, Gabriel; Santos Costa, Sofia; Caneiras, Catia; Poirel, Laurent; Amaral, Andreia J.; Pomba, ConstançaResistance to carbapenems in Enterobacterales poses a threat to health care systems worldwide since those infections are associated with high mortality and limited treatment options. The latest European reports show that some southern European countries are almost endemic for carbapenemase-producing Enterobacterales (CPEs). Mirroring the European tendency, Portugal has been observing a steady increase in the oc...