22 documents found, page 1 of 3

Untangling sex differences in glia-to-neuron communication in chronic alcohol e...

Excessive alcohol consumption is global health challenge with profound neurobiological consequences. Our laboratory has shown that alcohol exposure induces reactive astrocytic changes, affecting gene expression, activity, and proliferation, while also altering microglial morphology and immune responses [1]. This study aims to characterise sex-specific effects of chronic alcohol consumption on the prefrontal cor...

Objective assessment of pull test scores in Parkinson’s disease under dynamic c...

Background: Postural instability is considered one of the most incapacitating motor symptoms and a primary cause of falls in Parkinson’s disease (PD), compromising patients’ autonomy and well-being. The traditional clinical examination used to evaluate this symptom designed by pull test is difficult to standardize and is not sensitive to subtle but significant postural changes. Inertial measurement units have e...

Deep learning models for improving Parkinson’s disease management regarding dis...

Background and objective: Motor diagnosis, monitoring and management of Parkinson’s disease (PD) focuses mainly on observational methods and, clinical scales, resulting in a subjective evaluation. Inertial sensors combined with artificial intelligence have emerged as a promising solution to help physicians perform early, differential, and objective quantification of motor symptoms over time. We hypothesize that...

Sociodemographic factors and biologic therapy exposure impacting health-related...

Funding Information: This work was supported by a research grant from the Portuguese Society of Rheumatology. Publisher Copyright: © The Author(s) 2025.; Psoriatic arthritis (PsA) is a very heterogeneous disease with significant impact on health-related quality-of-life (HRQoL). Our objective was to assess and identify predictors of HRQoL in a 3-year follow-up period among PsA patients. Patients with PsA include...

Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0...

Background: Conventional oral levodopa therapy for the treatment of Parkinson's disease can be associated with variations in plasma concentrations. Levodopa infusion strategies might provide more consistent drug delivery and fewer motor fluctuations. We aimed to assess the safety and efficacy of a continuous 24 h/day subcutaneous infusion of ND0612 (a levodopa-carbidopa solution) compared with oral immediate-re...

CheckAP

Publisher Copyright: © 2024, Sociedade Portuguesa de Reumatologia. All rights reserved.; Background: The percentage of Portuguese psoriasis patients with psoriatic arthritis is unknown but musculoskeletal complaints related to PsA affect up to a third of patients. Dermatologists can identify early PsA as skin symptoms often precede joint symptoms in 80% of patients. Efficient and easy to perform screening tools...

Deciphering the astrocytic and synaptic changes under chronic alcohol exposure ...

Drug abuse is characterized by a compulsive and persistent drug-seeking behaviour, despite the harmful emotional, physical and social consequences. Our laboratory has previously found that the neuronal-glial crosstalk is critical in relaying the changes caused by acute exposure to psychoactive drugs through neuroimmune mechanisms. We have also reported that microglia can engulf postsynaptic components in the pr...

Obesity- attributable costs of absenteeism among working adults in Portugal

Funding This study was funded by Fundação para Ciência e Tecnologia, FCT, I. P. reference SFRH (PD/BD/135589/2018) and by 2 Comprehensive Health Research Center (CHRC) (UIDP/04923/2020).; BACKGROUND: Obesity leads to poor health outcomes and may adversely affect work productivity. This study, aimed to investigate the obesity- attributable costs of absenteeism among working adults in Portugal. METHODS: The study...

Mass Spectrometry Based Forest Tree Metabolomics

"This thesis describes the application of mass spectrometry (MS)-based metabolomics approaches to study the metabolite responses of Pinus pinaster to pinewood nematode (PWN) infection. The PWN Bursaphelenchus xylophilus is the causal agent of the pine wilt disease (PWD), a serious pathology to conifer forests with devasting ecological and economic impact."

Comparison of different methods of medical legal age classification using ROC c...