54 documents found, page 1 of 6
Pharmacological NF-κB inhibition decreases cisplatin chemoresistance in muscle-...
Gil da Costa, Rui; Levesque, C; Bianchi-Frias D; Chatterjee, P; Lam, HM; Santos, C; Coleman, IM; Ferreirinha, P; Vilanova, M; Pinto da Cunha, NMost patients with muscle-invasive bladder cancer (MIBC) are not cured with platinum chemotherapy. Up-regulation of nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) is a major mechanism underlying chemoresistance, suggesting that its pharmacological inhibition may increase platinum efficacy. NF-κB signaling was investigated in two patient cohorts. The Cancer Genome Atlas (TCGA) was used to...
Próteses totais primárias da anca com um recuo superior a 15 anos a propósito d...
Corte-Real, C; Ferreira, I; Mendes, J; Dias, P; Mendonça, A; Cura-Mariano, J; Lucas, F; Judas, FO Ortopedista dispõe, atualmente, de um leque alargado de endopróteses articulares primárias da anca para o tratamento da artropatia degenerativa ou inflamatória e, bem assim para a cirurgia reconstrutiva da anca traumática, que incluem implantes cimentados, não cimentados, híbridos, revestidos ou não com biocerâmicos, com diversas cúpulas de fricção articular. A implantação de uma prótese total da anca represe...
Skin temperature response to thermal stimulus in patients with hyperhidrosis: A...
Carvalho, F; Magalhaes, C; Fernandez-Llimos, F; Mendes, J; Goncalves, JABS TRACT Primary hyperhidrosis (HH), the excessive sweating exceeding physiological demand, has been associated to a complex dysfunction of the autonomic nervous system which may explain the disfunction in sweating but may also cause unrevealed alterations in skin blood flow regulation. In fact, HH patients present a sympathetic over-function with less reflex bradycardia in response to the Valsalva maneuver an...
EGFR Assessment in Lung Cancer CT Images: Analysis of Local and Holistic Region...
Silva, F; Pereira, T; Morgado, J; Frade, J; Mendes, J; Freitas, C; Negrao, E; Lima, BF; Silva, M; Madureira, AJ; Ramos, I; Hespanhol, V; Costa, JLStatistics have demonstrated that one of the main factors responsible for the high mortality rate related to lung cancer is the late diagnosis. Precision medicine practices have shown advances in the individualized treatment according to the genetic profile of each patient, providing better control on cancer response. Medical imaging offers valuable information with an extensive perspective of the cancer, openi...
Association between nutritional and functional status indicators with caregiver...
de Sousa, OV; Mendes, J; Amaral, TeresaAim To investigate the association between nutritional and functional status of Alzheimer's disease patients and caregivers' burden. Methods A cross-sectional study was conducted among 79 community-dwelling Alzheimer's disease patients living with their caregivers. Caregivers' burden was assessed using the Zarit Burden-Interview. Multinomial logistic regressions were carried out using caregivers' burden as the ...
Validation of the Telephone-Administered Version of the Mediterranean Diet Adhe...
Gregório, MJ; Rodrigues, AM; Salvador, C; Dias, S; Sousa, R; Mendes, J; Coelho, P; Branco, J; Lopes, C; Martínez-González, M; Graça, P; Canhão, HA 14-Item Mediterranean Diet Adherence Screener (MEDAS) questionnaire was developed and validated in face-to-face interviews, but not via telephone. The aims of this study were to evaluate the validity and reliability of a telephone-administered version of the MEDAS as well as to validate the Portuguese version of the MEDAS questionnaire. A convenience community-based sample of adults (n = 224) participated in ...
Nutritional and Functional Indicators and Their Association With Mortality Amon...
Sousa, Odete; Mendes, J; Amaral, TeresaThis study investigated how different nutritional and functional status indicators are associated with mortality in patients with Alzheimer's disease (AD). A prospective cohort study was conducted among 79 community-dwelling older adults with AD. Follow-up was 60 months. Undernutrition status was evaluated by Mini Nutritional Assessment (MNA), body mass index, mid-arm muscle circumference (MAMC), calf circumfer...
Handgrip Strength and Its Association With Hydration Status and Urinary Sodium-...
Mendes, J; Padrão, Patrícia; Moreira, Pedro; Santos, Alejandro; Borges, Nuno; Afonso, Cláudia; Maria Rita Negrão; Amaral, TeresaObjective: Older adults present higher risk of functional disability detected by handgrip strength and an increased risk of poor health conditions, such as dehydration and low values of the sodium-to-potassium (Na/K) ratio. This study aimed to quantify the association of hydration status and Na/K ratio with handgrip strength, based on the urinary excretion of older adults. Methods: A cross-sectional study was c...
Sitting time and associated factors among Portuguese older adults: results from...
Sousa, AS; Mendes, J; Guerra, RS; Padrão, P; Moreira, P; Santos, A; Borges, N; Afonso, C; Martins, C; Ferro, G; Amaral, TFOlder adults are particularly susceptible to sedentary behaviours. Sitting time has been increasingly referred to as a potentially modifiable risk factor in the prevention of chronic diseases. Identifying factors associated with sitting time, particularly those that are modifiable, will allow for more effective public health strategies. This study aimed to describe sitting time among Portuguese older adults and...
Pre-training autoencoder for lung nodule malignancy assessment using CT images
Silva, F; Pereira, T; Frade, J; Mendes, J; Freitas, C; Hespanhol, V; Costa, JL; Cunha, A; Oliveira, HPLung cancer late diagnosis has a large impact on the mortality rate numbers, leading to a very low five-year survival rate of 5%. This issue emphasises the importance of developing systems to support a diagnostic at earlier stages. Clinicians use Computed Tomography (CT) scans to assess the nodules and the likelihood of malignancy. Automatic solutions can help to make a faster and more accurate diagnosis, which...