62 documents found, page 1 of 7
Migração de uma prótese de hérnia inguinal: relato de caso
Mendes, Maria; Pacheco, Andreia; Russo, Carlos; Martins, Maria João; Mendes, Maria; Pacheco, Andreia; Russo, Carlos; Martins, Maria JoãoIntrodução: A hérnia inguinal é um tipo de hérnia da parede abdominal e constitui a patologia cirúrgica mais comum nos cuidados de saúde primários. A infeção local e a formação de seroma ou hematoma são complicações comuns, ao contrário de complicações mais graves, como a migração da prótese ou a perfuração de órgãos adjacentes. Descrição do caso: Utente do sexo masculino, de 57 anos de idade, com múltiplos ant...
Perspectives of a Group of Residents Regarding the Article “Strategies for the ...
Braga, Mariana; Mendes, Maria; Casimiro, Mariana; Varandas, Rodrigo; Serra, JoanaN/a.; N/a.
Communication paradoxes: Brands as People and People as Brands
Mendes, MariaWe live in a time when people increasingly want to build their identity as a brand and brands want to appear human. This article explores the paradoxes inherent in contemporary communication, the increasing humanization of brands and the emergence of people who build their identities as brands and the impact of the evolution of digital platforms. This phenomenon raises important questions about authenticity, et...
Analysis of the biological effect of Carica papaya leaf extracts on the viabili...
Canteiro, Beatriz; Mendes, Maria; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, Miguel; Gomes, AnitaBackground – Sickle cell disease (SCD) is a genetic blood disorder caused by mutations in the β-globin gene that affects the shape and transport of red blood cells in blood vessels, leading to various clinical complications. The pharmacological reactivation of fetal hemoglobin (HbF) through compounds such as hydroxyurea (HU), is one of the currently available treatments, however, their safety concerns and expen...
Investigating the role of symptom valorisation in tuberculosis patient delay in...
de Morais, Margarida; Sousa, Sofia; Marques, Jéssica; Moniz, Marta; Duarte, Raquel; Leite, Andreia; Soares, Patricia; Carreira, Mário; Pereira, SofiaBackground: Diagnosis delay contributes to increased tuberculosis (TB) transmission and morbimortality. TB incidence has been decreasing in Portugal, but median patient delay (PD) has risen. Symptom valorisation may determine PD by influencing help-seeking behaviour. We aimed to analyse the association between symptom valorisation and PD, while characterising individuals who disregarded their symptoms. Methods:...
Estudo sobre a origem do enrugamento do miolo da noz
Farinha, Daniela; Mendes, Maria; Mota Barroso, João; Peixe, Augusto; Dias, António; Rato, Ana ElisaA Nogueira (Juglans regia L.) é uma das espécies de frutos secos mais consumidas que tem vindo a ganhar importância com a implantação de novos pomares de Norte a Sul do país. A formação incompleta da semente, com o enrugamento do miolo associado, é um dos problemas que deprecia a qualidade e para o qual não existe um controle eficaz por se desconhecer a sua origem. A acumulação das reservas ao nível da semente ...
Can Celecoxib Assay in Preclinical Studies Be Improved?
Mendes, Maria; Sousa, João; Pais, Alberto; Vitorino, CarlaCelecoxib, a cyclooxygenase-2 inhibitor (COX-2), is attracting considerable interest owing to its potential anticancer activity. The repurposing strategy of this drug, however, requires preclinical assessment involving the use of increasingly improved analytical methods. In this work, a rapid, accurate, precise, and sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed f...
A two-pronged approach against glioblastoma: drug repurposing and nanoformulati...
Mendes, Maria; Branco, Francisco; Vitorino, Rui; Sousa, João; Pais, Alberto; Vitorino, CarlaGlioblastoma (GB) is one of the most lethal types of neoplasms. Its biologically aggressive nature and the presence of the blood-brain barrier (BBB) limit the efficacy of standard therapies. Several strategies are currently being developed to both overcome the BBB and deliver drugs site specifically to tumor cells. This work hypothesizes a two-pronged approach to tackle GB: drug repurposing with celecoxib (CXB)...
Effects of Quercetin in transcriptional and post-transcriptional regulation of ...
Canteiro, Beatriz; Mendes, Maria; Jacques, Filipa; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, MiguelHemoglobinopathies are a group of inherited blood disorders that primarily affect red blood cells. The most common type is known as sickle cell anemia (SCA). It is characterized by mutations in the HBB gene, which encodes the β-subunit of human hemoglobin, giving rise to hemoglobin S (HbS). When deoxygenated, HbS polymerizes in the red blood cell, giving it a sickle shape and making it rigid and fragile. Fetal ...
Effects of quercetin in transcriptional and post-transcriptional regulation of ...
Canteiro, Beatriz; Mendes, Maria; Jacques, Filipa; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, MiguelSickle Cell anemia (SCA) is a hereditary hemoglobinopathy with the formation of hemoglobin S, associated with severe health outcomes. Currently, induction of fetal hemoglobin (HbF) is one of the most promising therapeutic strategies. Here we aimed to assess the potential of the natural compound Quercetin, in transcriptional expression of globin and HbF regulatory/silencing genes. In this study, the K562 cell li...