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Assessing the Potential of Brewer’s Spent Grain to Enhance Cookie Physicochemic...

Nicolai, Marisa; Palma, Maria Lídia; Reis, Ricardo; Amaro, Rúben; Fernandes, Jaime; Gonçalves, Elsa M.; Silva, Mafalda; Lageiro, Manuela

Copyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland.; Brewers’ spent grain (BSG), the major by-product of the brewery industry, has high nutritional value, making it suitable for upcycling into products such as healthy, and sustainable cookies. Nonetheless, the incorporation of BSG in cookies can impact their quality, given the increased fiber and protein content. This work explored the effect o...


Exploring the Benefits of Nutritional and Chemical Characteristics of Touriga N...

Pereira, Paula; Palma, Maria Lídia; Palma, Carla; Borges, Carlos; Maurício, Elisabete; Fernando, Ana Luísa; Duarte, Maria Paula; Lageiro, Manuela

Funding Information: This research was funded by the Foundation for Science and Technology (FCT), under the grants UIDB/04567/2020, UIDP/04567/2020 to CBIOS, MEtRICs, through FCT/MCTES (https://doi.org/59210.54499/UIDB/04077/2020, https://doi.org/10.54499/UIDP/04077/2020), and UIDB/50006/2020 DOI 10.54499/UIDB/50006/2020 to LAQV/Requimte. Publisher Copyright: © 2024 by the authors.; Environmental degradation le...


Acetylcholinesterase Choline-Based Ionic Liquid Inhibitors: In Vitro and in Sil...

Siopa, Filipa; Frade, Raquel F. M.; Diniz, Ana; Andrade, Joana M.; Nicolai, Marisa; Meirinhos, Ana; Lucas, Susana D.; Marcelo, Filipa

COMPETE Programme: SAICTPAC/0019/2015 IF/00780/2015 Project no. 022161; Monocationic and dicationic cholinium ionic liquids (ILs) were synthesized and evaluated as acetylcholinesterase (AChE) inhibitors with in vitro and in silico models, and their cytotoxicity was assessed using human cell lines from skin (CRL-1502) and colon cancer (CaCo-2). The ILs with a longer alkyl chain were stronger AChE inhibitors, the...


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