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Dhvar5-chitosan nanogels and their potential to improve antibiotics activity
Costa, B; Alves, PM; Fonseca, DR; Campos, F; Monteiro, AC; Shahrour, H; Gomes, A; Costa, F; Gomes, P; Martínez-de-Tejada, G; Monteiro, C; Martins, MCLInfection is one of the main causes of orthopedic implants failure, with antibiotic-resistant bacteria playing a crucial role in this outcome. In this work, antimicrobial nanogels were developed to be applied in situ as implant coating to prevent orthopedic-device-related infections. To that regard, a broad-spectrum antimicrobial peptide, Dhvar5, was grafted onto chitosan via thiol-norbornene "photoclick" chemi...
Dhvar5- and MSI78-coated titanium are bactericidal against methicillin-resistan...
Costa, B; Coelho, J; Silva, V; Shahrour, H; Costa, NA; Ribeiro, AR; Santos, SG; Costa, F; Martínez-de-Tejada, G; Monteiro, C; Martins, MCLInfection is one of the major issues associated with the failure of orthopedic devices, mainly due to implant bacterial colonization, biofilm formation, and associated antibiotic resistance. Antimicrobial peptides (AMP) are a promising alternative to conventional antibiotics given their broad-spectrum of activity, low propensity to induce bacterial resistance, and ability to modulate host immune responses. Dhva...