10 documents found, page 1 of 1
Proteomic analysis of liver from finishing beef cattle supplemented with a rume...
Lopes, Mariana Mescouto; Brito, Thaís Ribeiro [UNESP]; Lage, Josiane Fonseca; Costa, Thaís Correia; Fontes, Marta Maria Dos SantosMade available in DSpace on 2022-05-01T05:29:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-07-01; Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Vitamin B and trace minerals are crucial molecular signals involved in many biological pathways; h...
Genome-wide identification and expression analysis of dormancy-associated gene ...
Souza, Gilza Barcelos de; Mendes, Tiago Antônio de Oliveira; Fontes, Patrícia Pereira; Barros, Vanessa de Almeida; Gonçalves, Amanda BonotoDormancy-Associated gene 1/Auxin Repressed protein (DRM1/ARP) genes are responsive to hormones involved in defense response to biotic stress, such as salicylic acid (SA) and methyl jasmonate (MeJA), as well as to hormones that regulate plant growth and development, including auxins. These characteristics suggest that this gene family may be an important link between the response to pathogens and plant growth an...
Synthesis and antimetastatic activity evaluation of cinnamic acid derivatives c...
Lima, Graziela Domingues de Almeida; Rodrigues, Michelle Peixoto; Moreira, Gabriela Alves; Mendes, Tiago Antônio de Oliveira; Siqueira, Raoni PaisIt is herein described the preparation and evaluation of antimetastatic activity of twenty-six cinnamic acid derivatives containing 1,2,3-triazolic portions. The compounds were prepared using as the key step the Copper(I)-catalyzed azide (A)-alkyne (A) cycloaddition (C) (CuAAC reaction), also known as click reaction, between alkynylated cinnamic acid derivatives and different benzyl azides. The reactions were c...
New antigens for the serological diagnosis of human visceral leishmaniasis iden...
Carvalho, Ana Maria Ravena Severino; Mendes, Tiago Antônio de Oliveira; Coelho, Eduardo Antonio Ferraz; Duarte, Mariana Costa; Menezes- Souza, DanielVisceral leishmaniasis (VL) still represents a serious public health problem in Brazil due to the inefficiency of the control measures currently employed, that included early diagnosis and treatment of human cases, vector control, euthanasia of infected dogs and, recently approved in Brazil, treatment with Milteforam drug. Effective clinical management depend largely on early and unequivocal diagnosis, however,...
Lipophosphoglycan 3 From Leishmania infantum chagasi Binds Heparin With Micromo...
Martins, Thaís Viana Fialho; Zeraik, Ana Eliza; Alves, Natália Oliveira; Oliveira, Leandro Licursi de; Mendes, Tiago Antônio de OliveiraLeishmania infantum chagasi is an intracellular protozoan parasite responsible for visceral leishmaniasis, a fatal disease in humans. Heparin-binding proteins (HBPs) are proteins that bind to carbohydrates present in glycoproteins or glycolipids. Evidence suggests that HBPs present on Leishmania surface participate in the adhesion and invasion of parasites to tissues of both invertebrate and vertebrate hosts. I...
Immunogenomic screening approach to identify new antigens for the serological d...
Elisei, Rutyanne Maria Tonelli; Matos, Christiane Santos; Carvalho, Ana Maria Ravena Severino; Chaves, Ana Thereza; Medeiros, Fernanda Alvarenga CardosoSerological tests are preferentially used for the diagnosis of Chagas’ disease (CD) during the chronic phase because of the low parasitemia and high anti-Trypanosoma cruzi antibody titers. However, the current methods showed several disadvantages, as contradictory or inconclusive results, mainly related to the characteristics of the antigens used, in general, crude or whole parasites, but also due to antigen pr...
N-dodecanoyl-homoserine lactone influences the levels of thiol and proteins rel...
Almeida, Felipe Alves de; Carneiro, Deisy Guimarães; Barros, Edvaldo; Pinto, Uelinton Manoel; Oliveira, Leandro Licursi deQuorum sensing is a cell-cell communication mechanism mediated by chemical signals that leads to differential gene expression in response to high population density. Salmonella is unable to synthesize the autoinducer-1 (AI-1), N-acyl homoserine lactone (AHL), but is able to recognize AHLs produced by other microorganisms through SdiA protein. This study aimed to evaluate the fatty acid and protein profiles of S...
Impact of the removal of N-terminal non-structured amino acids on activity and ...
Ventorim, Rafaela Zandonade; Mendes, Tiago Antônio de Oliveira; Trevizano, Larissa Mattos; Camargos, Ana Maria dos Santos; Guimarães, Valéria MontezeXylanases catalyze the random hydrolysis of xylan backbone from plant biomass and thus, they have application in the production of biofuels, Kraft pulps biobleaching and feed industry. Here, xylanases derived from Orpinomyces sp. PC-2 were engineered guided by molecular dynamics methods to obtain more thermostable enzymes. Based on these models, 27 amino acid residues from the N-terminal were predicted to reduc...
Regulatory monocytes in helminth infections: insights from the modulation durin...
Mendes, Tiago Antônio de Oliveira; Passos, Lívia Silva Araújo; Gazzinelli-Guimarães, Pedro Henrique; Guimarães, Ana Clara GazzinelliWhile the macrophage polarization is well characterized in helminth infections, the natural heterogeneity of monocytes with multiple cell phenotypes might influence the outcome of neglected diseases, such hookworm infection. Here, we report the profile of monocytes in human hookworm infections as a model to study the regulatory subpopulation of monocytes in helminth infections. Blood samples were collected from...
Epitope mapping of the HSP83.1 protein of Leishmania braziliensis discloses nov...
Souza, Daniel Menezes; Mendes, Tiago Antônio de Oliveira; Gomes, Matheus de Souza; Cunha, João Luís Reis; Nagem, Ronaldo Alves PintoGold standard serological diagnostic methods focus on antigens that elicit a strong humoral immune response that is specific to a certain pathogen. In this study, we used bioinformatics approaches to identify linear B-cell epitopes that are conserved among Leishmania species but are divergent from the host species Homo sapiens and Canis familiaris and from Trypanosoma cruzi, the parasite that causes Chagas dise...