3 documents found, page 1 of 1
Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea gland...
Lopes, Flavia C. M. [UNESP]; Rocha, Ana; Pirraco, Ana; Regasini, Luis O. [UNESP]; Silva, Dulce Helena Siqueira [UNESP]Made available in DSpace on 2013-08-28T14:10:22Z (GMT). No. of bitstreams: 1 WOS000267598400001.pdf: 685962 bytes, checksum: ea605f9468c4f56803868d7155d74981 (MD5); Made available in DSpace on 2013-09-30T18:05:46Z (GMT). No. of bitstreams: 2 WOS000267598400001.pdf: 685962 bytes, checksum: ea605f9468c4f56803868d7155d74981 (MD5) WOS000267598400001.pdf.txt: 46939 bytes, checksum: 7e0d4136f5311e84f32ea9e048578ccd (...
Neurokinin-1 receptor, a new modulator of lymphangiogenesis in obese-asthma phe...
Ramalho, Renata; Almeida, Joana; Fernandes, Rúben; Costa, Raquel; Pirraco, Ana; Guardão, Luísa; Delgado, Luís; Moreira, André; Soares, RaquelAims Obesity and asthma are widely prevalent and associated disorders. Recent studies of our group revealed that Substance P (SP) is involved in pathophysiology of obese-asthma phenotype in mice through its selective NK1 receptor (NK1-R). Lymphangiogenesis is impaired in asthma and obesity, and SP activates contractile and inflammatory pathways in lymphatics. Our aim was to study whether NK1-R expression was in...
Neurogenic inflammation in allergen-challenged obese mice: a missing link in th...
Ramalho, Renata; Almeida, Joana; Beltrão, Marília; Pirraco, Ana; Costa, Raquel; Sokhatska, Oksana; Guardão, Luísa; Palmares, CarmoA number of studies have shown an association between obesity and asthma. Controversy remains on the mechanisms supporting this association. In this study we aimed to assess neurogenic inflammation in a model of diet-induced obesity and allergen-challenged mice. High fat diet-induced (HFD) obese Balb/c mice were sensitized and challenged with ovalbumin (OVA). Glucose, insulin, OVA-specific IgE and substance P (...