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A hint for the obesity paradox and the link between obesity, perirenal adipose ...

Preza-Fernandes, J; Passos, P; Mendes-Ferreira, M; Rodrigues, AR; Gouveia, Alexandra; Fraga, A; Medeiros, R; Ribeiro, R

Increasing evidence supports a role for local fat depots in cancer outcomes. Despite the robust positive association of obesity with renal cell carcinoma (RCCa) diagnosis, increased adiposity is inversely related to RCCa oncological outcomes. Here, we sought to ascertain whether imagiologically assessed local fat depots associate with RCCa progression and survival and account for this apparent paradox. A retros...


Skeletal muscle–adipose tissue–tumor axis: Molecular mechanisms linking exercis...

Rocha-Rodrigues, S; Matos, M; Afonso, J; Mendes-Ferreira, M; Abade, E; Teixeira, E; Silva, B; Murawska-Cialowicz, E; Oliveira, MJ; Ribeiro, R

Increased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these eff...


Urocortin-2 improves right ventricular function in pulmonary arterial hypertension

Mendes-Ferreira, M; Adão, R; Mendes- Ferreira, P; Maia- Rocha, C; Santos-Ribeiro, D; Pinto, C; Pimentel, L; Potus, F; Breuils-Bonnet, S; Provencher, S


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