6 documents found, page 1 of 1
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in...
Borges, Vítor; Duque, Mariana Perez; Martins, João Vieira; Vasconcelos, Paula; Ferreira, Rita; Sobral, Daniel; Pelerito, Ana; de Carvalho, Isabel LopesPathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the hi...
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in...
Borges, Vítor; Duque, Mariana Perez; Martins, João Vieira; Vasconcelos, Paula; Ferreira, Rita; Sobral, Daniel; Pelerito, Ana; de Carvalho, Isabel LopesPathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the hi...
Real-World Characterization of the Portuguese Population Living with HIV who In...
Serrão, Rosário; Mansinho, Kamal; Maltez, Fernando; Marques, Nuno; Carvalho, Alexandre; Pazos, Rosário; Zagalo, Alexandra; Mendez, JosefinaIntroduction: Although raltegravir has been available since 2007, data are lacking on the Portuguese population living with HIV who initiated this antiretroviral therapy. Hence, this study aimed to characterize the patients who initiated raltegravir-based regimens between January 2015 and December 2017, on sociodemographics, clinical features, and treatment satisfaction.Material and Methods: Observational, retr...
Chronic hepatitis C treatment in HIV co‐infection in Portugal: Results from a c...
Miranda, Ana; Mendez, Josefina; Serrão, Rosário; Vale, Francisco; Manata, Maria José; Pinto, Sara; Gomes, André; Valente, Cristina; Pacheco, PatríciaDirect-acting antiviral drugs (DAAs) have recently changed the paradigm of hepatitis C therapy, significantly improving treatment response rates, patient life expectancy and quality of life. In Portugal, sofosbuvir (SOF) and SOF/ledipasvir (SOF/LDV) were fully reimbursed by the National Health System since early 2015 and generalized use of interferon-free DAA based regimens became current practice. During 2016,...
Genetic diversity and population genetic analysis of Donax vittatus (Mollusca: ...
Fernandez-Perez, Jenyfer; Froufe, Elsa; Nanton, Ana; Gaspar, Miguel; Mendez, JosefinaIn this study, the genetic diversity of Donax vittatus across the Iberian Peninsula was investigated using four mitochondrial (COI, Cytb, 16S F and M types) and three nuclear (H8, 18S and 285) genes. These same molecular markers were also sequenced in D. semistriatus and D variegatus to address the phylogenetic relationships of the species of the genus Donax common along the European coasts. Our results showed ...
Daño al sistema nervioso inducido por nanopartículas : toxicidad celular induci...
Laffon, Blanca; Iglesias, Vanessa; Costa, Carla; Costa, Solange; Teixeira, João Paulo; Mendez, JosefinaLas nanopartículas (NP) de óxidos metálicos, como el dióxido de titanio (TiO2) y el óxido de zinc (ZnO), se utilizan en una gran variedad de aplicaciones industriales y médicas, incluyendo materiales de alta tecnología, plásticos, pinturas, implantes ortopédicos artificiales, derivados de papel, cosméticos y protectores solares. Los estudios sobre los efectos de estas NP en el sistema nervioso son muy escasos. ...