130 documents found, page 1 of 13
Injectable and implantable hydrogels for localized delivery of drugs and nanoma...
Pouso, Manuel António do Rosário; Melo, Bruna Daniela Lopes; Gonçalves, Joaquim; Louro, Ricardo; Mendonça, António; Correia, Ilídio Joaquim SobreiraMultiple chemotherapeutic strategies have been developed to tackle the complexity of cancer. Still, the outcome of chemotherapeutic regimens remains impaired by the drugs’ weak solubility, unspecific biodistribution and poor tumor accumulation after systemic administration. Such constraints triggered the development of nanomaterials to encapsulate and deliver anticancer drugs. In fact, the loading of drugs into...
Development of dual-crosslinked Pluronic F127/Chitosan injectable hydrogels inc...
Pouso, Manuel António do Rosário; Melo, Bruna L.; Gonçalves, Joaquim; Mendonça, António; Correia, I.J.; Diogo, Duarte de MeloNanomaterials with responsiveness to near-infrared light can mediate the photoablation of cancer cells with an exceptional spatio-temporal resolution. However, the therapeutic outcome of this modality is limited by the nanostructures’ poor tumor uptake. To address this bottleneck, it is appealing to develop injectable in situ forming hydrogels due to their capacity to perform a tumor-confined delivery of the na...
Hyaluronic acid-functionalized graphene-based nanohybrids for targeted breast c...
Lima-Sousa, Rita; Melo, Bruna L.; Mendonça, António; Correia, I.J.; Melo-Diogo, Duarte deNanomaterials’ application in cancer therapy has been driven by their ability to encapsulate chemotherapeutic drugs as well as to reach the tumor site. Nevertheless, nanomedicines’ translation has been limited due to their lack of specificity towards cancer cells. Although the nanomaterials’ surface can be coated with targeting ligands, such has been mostly achieved through non-covalent functionalization strate...
Injectable hydrogels for the delivery of nanomaterials for cancer combinatorial...
Lima-Sousa, Rita; Alves, Cátia; Melo, Bruna L.; Costa, Francisco J. P.; Nave, Micaela; Moreira, André F.; Mendonça, António; Correia, I.J.Progress in the nanotechnology field has led to the development of a new class of materials capable of producing a temperature increase triggered by near infrared light. These photothermal nanostructures have been extensively explored in the ablation of cancer cells. Nevertheless, the available data in the literature have exposed that systemically administered nanomaterials have a poor tumor-homing capacity, hi...
Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in U...
Santos, Adalberto; Póvoa, Pedro; Paixão, Paulo; Mendonça, António; Barata, Luís Manuel TabordaCOVID-19 is an infectious disease caused by Coronavirus 2 (SARS-CoV-2) that may lead to a severe acute respiratory syndrome. Such syndrome is thought to be related, at least in part, to a dysregulation of the immune system which involves three main components: hyperactivity of the innate immune system; decreased production of type 1 Interferons (IFN) by SARS-CoV-2-infected cells, namely respiratory epithelial c...
Characterization of physicochemical parameters of “amarelo da beira baixa”
Santos, Tomás; Resende, M.; Mendonça, António; Estevinho, Letícia M.; Paulo, Luísa; Anjos, Ofélia“Amarelo da Beira Baixa” cheese is a cured cheese, produced with raw milk from sheep’s or sheep’s and goat’s, with a semi-hard or semi-soft paste and characterized by a yellow color. It is produced in the central region of Portugal, namely Castelo Branco, with a Protected Designation of Origin (PDO). These cheeses represent 52.6% of the cheeses from Beira Baixa region, which accounting for 25% of the Portugal c...
Lições de macroeconomia: uma introdução
Mendonça, António; Magriço, Vítor; Vale, Sofia; Abreu, Alexandre; Cunha, ValentinoO livro que agora se publica, sob a forma de lições de macroeconomia, é o resultado de 3 anos de trabalho na lecionação da disciplina de Economia II, das licenciaturas em Economia, Matemática Aplicada à Economia e à Gestão e Estudos Gerais, do Instituto Superior de Economia e Gestão da Universidade de Lisboa. Estas Lições de Macroeconomia são o resultado de uma experiência pedagógica de lecionação de uma discip...
Europe at the crossroads of the COVID-19 crisis: integrated macroeconomic polic...
Mendonça, António; Vale, SofiaThe economic crisis triggered by the COVID–19 pandemic once again raises doubts about the eurozone’s ability to deal with joint economic problems given its dissimilar dynamics and asymmetries. This chapter contributes to a paradigm shift in the governance of the euro area towards a more comprehensive and integrated approach. Two dimensions of this paradigm are considered. First, the need for a change in the eco...
Poly(2-ethyl-2-oxazoline) functionalized reduced graphene oxide: Optimization o...
Sousa, Ana Rita Lima; Alves, Cátia; Melo, Bruna L.; Moreira, André; Mendonça, António; Correia, I.J.; Diogo, Duarte de MeloThe high near infrared (NIR) absorption displayed by reduced graphene oxide (rGO) nanostructures renders them a great potential for application in cancer photothermal therapy. However, the production of this material often relies on the use of hydrazine as a reductant, leading to poor biocompatibility and environmental-related issues. In addition, to improve rGO colloidal stability, this material has been funct...
Combining Photothermal‐Photodynamic Therapy Mediated by Nanomaterials with Immu...
Sousa, Rita Lima; Melo, Bruna L.; Alves, Cátia; Moreira, André; Mendonça, António; Correia, I.J.; Diogo, Duarte de MeloThe pursuit of effective treatments for metastatic cancer is still one of the most intensive areas of research in the biomedical field. In a not-so-distant past, the scientific community has witnessed the rise of immunotherapy based on immune checkpoint inhibitors (ICIs). This therapeutic modality intends to abolish immunosuppressive interactions, re-establishing T cell responses against metastasized cancer cel...