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Outcomes in Guillain-Barré Syndrome Following a Second Therapeutic Cycle – A Si...

Faustino, P; Coutinho, M; Brum, M; Medeiros, L; Ladeira, F

Introduction: The treatment of Guillain-Barré Syndrome (GBS) with intravenous immunoglobulin (IVIg) or plasma exchange (PE) reduces time to clinical recovery. Although sometimes used in clinical practice, the benefit of a second treatment cycle is of unproven benefit. Aims: Our aim was to compare GBS prognosis in patients treated with one or two cycles of IVIg or PE. Methods: We selected patients with electroph...


A Role for Superficial Heat Therapy in the Management of Non-Specific, Mild-to-...

Freiwald, J; Magni, A; Fanlo-Mazas, P; Paulino, E; Medeiros, L; Moretti, B; Schleip, R; Solarino, G

Low back pain (LBP) is a leading cause of disability. It significantly impacts the patient's quality of life, limits their daily living activities, and reduces their work productivity. To reduce the burden of LBP, several pharmacological and non-pharmacological treatment options are available. This review summarizes the role of superficial heat therapy in the management of non-specific mild-to-moderate LBP. Fir...


Contralateral Upper Limb Weakness Following Botulinum Toxin A Injection for Pos...

Camões- Barbosa, A; Mendes Ribeiro, I; Medeiros, L

Botulinum toxin type A has been approved for spasticity management in poststroke patients. The adverse effects are generally of two types: those related to local injection; and those related to the systemic effects from spread of the toxin. Contralateral weakness after botulinum toxin A treatment is a rarely reported adverse effect. We report the case of a 33-year-old female who had been receiving regular injec...


Quality of Life in Subjects with Upper- and Lower-Limb Spasticity Treated with ...

Fheodoroff, K; Rekand, T; Medeiros, L; Koßmehl, P; Wissel, J; Bensmail, D; Scheschonka, A; Flatau-Baqué, B; Simon, O; Dressler, D; Simpson, DM

Background: We evaluated quality of life among subjects with upper- and lower-limb spasticity who received escalating doses of incobotulinumtoxinA (total body doses up to 800 U) in the prospective, single-arm, dose-titration TOWER study. Methods: In this exploratory trial, subjects (N = 155; 18-80 years of age) with upper- and lower-limb spasticity due to cerebral causes who were deemed to require total body do...


Contralateral Upper Limb Weakness Following Botulinum Toxin A Injection for Pos...

Camões-Barbosa, A; Ribeiro, I; Medeiros, L

Botulinum toxin type A has been approved for spasticity management in poststroke patients. The adverse effects are generally of two types: those related to local injection; and those related to the systemic effects from spread of the toxin. Contralateral weakness after botulinum toxin A treatment is a rarely reported adverse effect. We report the case of a 33-year-old female who had been receiving regular injec...


Screening for Pompe disease in a Portuguese high risk population

Almeida, V; Conceição, I; Fineza, I; Coelho, T; Silveira, F; Santos, M; Herrero Valverde, A; Geraldo, A; Maré, R; Aguiar, TC; Mendonça, C; Martins, J

Pompe disease is a rare metabolic disorder with available enzymatic replacement therapy. Contrasting with the classic infantile form, the others subtypes have a heterogeneous presentation that makes an early and accurate diagnosis difficult. We conducted a prospective, multicenter, observational study to identify undiagnosed patients. During a one-year period, patients followed in Portuguese neuromuscular outpa...


Screening for Pompe Disease in a Portuguese High Risk Population

Almeida, V; Conceição, I; Fineza, I; Coelho, T; Silveira, F; Santos, M; Valverde, A; Geraldo, A; Maré, R; Aguiar, TC; Mendonça, C; Martins, J

Pompe disease is a rare metabolic disorder with available enzymatic replacement therapy. Contrasting with the classic infantile form, the others subtypes have a heterogeneous presentation that makes an early and accurate diagnosis difficult. We conducted a prospective, multicenter, observational study to identify undiagnosed patients. During a one-year period, patients followed in Portuguese neuromuscular outpa...



Transverse myelitis.

Monteiro, T C; Esperança, P; Baptista, I; Medeiros, L; Candido, J

The authors report three clinical cases of acute transverse myelitis in young patients with emphasis given to the seriousness of this kind of pathology, the need to exclude a potentially treatable cause and the controversial corticosteroid treatment.; The authors report three clinical cases of acute transverse myelitis in young patients with emphasis given to the seriousness of this kind of pathology, the need ...

Date: 1995   |   Origin: Acta Médica Portuguesa

Mielite Transversa

Monteiro, T; Esperança, P; Baptista, I; Medeiros, L; Cândido, J

Os autores apresentam três casos de mielite transversa de instalação aguda em doentes jovens, salientando a possível gravidade do quadro neurológico, a necessidade de excluir uma causa potencialmente tratável e a controvérsia da terapêutica com corticosteroides.


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