2 documents found, page 1 of 1
New CTX-M group conferring β-Lactam resistance: A compendium of phylogenetic in...
Mendonça, Jacinta; Guedes, Carla; Silva, Carina; Sá, Sara; Oliveira, Marco; Accioly, Gustavo; Baylina, Pilar; Barata, Pedro; Pereira, CláudiaThe production of extended-spectrum β-lactamases (ESBLs) is the main defense mechanism found in Gram negative bacteria. Among all the ESBLs, the CTX-M enzymes appear as the most efficient in terms of dissemination in different epidemiological contexts. CTX-M enzymes exhibit a striking plasticity, with a large number of allelic variants distributed in several sublineages, which can be associated with functional ...
Phylogenetic Insights of β-lactam resistance of the CTX-M family
Coelho, Pedro Barata; Mendonça, Jacinta; Silva, Carina; Baylina, Pilar; Fernandes, Ruben; Guedes, CarlaBacterial resistance is a major public health concern, particularly against β-lactam antibiotics, one of the most widely used antibacterial drugs. The production of extended-spectrum β-lactamases (ESBLs) is the main defense mechanism found in Gram negative bacteria. Among all the ESBLs, the CTX-M enzymes appear as the most efficient in terms of diffusion in different epidemiological contexts, outnumbering the o...