6 documents found, page 1 of 1
Impact of schooling in the HIV/AIDS prevalence among Brazilian transgender women
Batista,Rafael Loch; Verduguez,Elisa dal Rosario; Inacio,Marlene; Cunha,Flávia Siqueira; Marques,Mateus Diniz; Gomes,Natália Lisboa Rosa AlmeidaABSTRACT Objective Discrimination and bullying are common conditions among LGBT people. During schooling, these practices compromising education. The aim of this study is to evaluate educational attainment among Brazilian transgender women (TW) and how their education level affects the risk of HIV infection. Study design a cross-sectional population-based study. Subjects and methods 95 adult TW were selected. I...
Combined pituitary hormone deficiency caused by PROP1 mutations: update 20 year...
Correa,Fernanda A.; Nakaguma,Marilena; Madeira,João L. O.; Nishi,Mirian Y.; Abrão,Milena G.; Jorge,Alexander A. L.; Carvalho,Luciani R.ABSTRACT The first description of patients with combined pituitary hormone deficiencies (CPHD) caused by PROP1 mutations was made 20 years ago. Here we updated the clinical and genetic characteristics of patients with PROP1 mutations and summarized the phenotypes of 14 patients with 7 different pathogenic PROP1 mutations followed at the Hospital das Clínicas of the University of Sao Paulo. In addition to defici...
An update of genetic basis of PCOS pathogenesis
Crespo,Raiane P.; Bachega,Tania A. S. S.; Mendonça,Berenice B.; Gomes,Larissa G.ABSTRACT Polycystic ovary syndrome (PCOS) is a common and complex endocrine disorder that affects 5-20% of reproductive age women. PCOS clinical symptoms include hirsutism, menstrual dysfunction, infertility, obesity and metabolic syndrome. There is a wide heterogeneity in clinical manifestations and metabolic complications. The pathogenesis of PCOS is not fully elucidated, but four aspects seem to contribute t...
Adjuvant radiotherapy for the primary treatment of adrenocortical carcinoma: ar...
Srougi,Victor; Bessa Junior,Jose; Tanno,Fabio Y.; Ferreira,Amanda M.; Hoff,Ana O.; Bezerra,João E.; Almeida,Cristiane M.; Almeida,Madson Q.ABSTRACT Purpose: To evaluate the role of ARDT after surgical resection of ACC. Materials and Methods: Records of patients from our institutional ACC database were retrospectively assessed. A paired comparison analysis was used to evaluate the oncological outcomes between patients treated with surgery followed by ARDT or surgery only (control). The endpoints were LRFS, RFS, and OS. A systematic review of the li...
Use of nonradioactive labeling to detect large gene rearrangements in 21-hydrox...
Cukier,Priscilla; Bachega,Tânia A. S. S.; Mendonça,Berenice B.; Billerbeck,Ana Elisa C.PURPOSE: To establish the Southern blotting technique using hybridization with a nonradioactive probe to detect large rearrangements of CYP21A2 in a Brazilian cohort with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH-21OH). METHOD: We studied 42 patients, 2 of them related, comprising 80 non-related alleles. DNA samples were obtained from peripheral blood, digested by restriction enzyme T...
Adrenocortical tumors: results of treatment and study of Weiss's score as a pro...
Lucon,Antonio Marmo; Pereira,Maria Adelaide; Mendonça,Berenice B.; Zerbini,Maria Claudia; Saldanha,Luiz B.; Arap,SamiPURPOSE: The differential diagnosis between benign and malignant adrenal cortical tumors circumscribed to the gland is controversial. One hundred and seven patients with adrenal cortex tumors (excluding those with primary hyperaldosteronism) were studied to assess the 5-year survival rate of adults, children, patients stratified by pathological stage, and patients stratified according to Weiss's score of <3 or ...