18 documents found, page 1 of 2

On the Identification of the Propofol PK/PD Model Using BIS Measurements

In this paper we analyse the use of different models to describe the effects of propofol in the induction of hypnosis on a patient during surgery. In particular, we consider the standard three-compartmental pharmacokinetics/pharmacodynamics Wiener model and a suitable reduction of it. The estimation of the parameters is based on real bispectral index scale surgical data and it is performed by using genetic algo...

Nonlinear controller for bispectral index tracking: Robustness and on-line retu...

In this paper, the performance of a control law designed for the automatic administration of propofol and of remifentanil in order to track a desired level for the bispectral index (BIS), used as a measure of the depth of anesthesia, is analyzed under the presence of model parameters uncertainties. It is theoretically proved and illustrated by simulations that under these circumstances the controller has a very...

Controller design for neuromuscular blockade level tracking based on optimal co...

The contribution of this paper is to present and compare two state-feedback design methods for the automatic control of the Neuromuscular Blockade Level (NMB) based on optimal control. For this purpose a parsimoniously parameterized model is used to describe the patient's response to a muscle relaxant. Due to clinical restrictions the controller action begins when the patient recovers after an initial drug bolu...

Fading histograms in detecting distribution and concept changes

A simplified control approach for the neuromuscular blockade level

In this paper a new simplified control scheme for the neuromuscular blockade level that only requires the knowledge of one model parameter is proposed. The control law is designed to track a desired target neuromuscular blockade level. Furthermore, an identification procedure to obtain the necessary model parameter is implemented. The results were validated by simulations based on real data collected during sur...

PH2 - A Public A Public Database for the Analysis of Dermoscopic Images

A simplified control scheme for the Depth of Anesthesia

In this paper a new simplified control sell( lie for the depth of anesthesia that only requires the knowledge of the half of the model parameters is proposed. TWO control laws are designed in parallel to control the amount of the hypnotic dose and the amount of the analgesic dose. Furthermore, an identification procedure to obtain the necessary model parameters is implemented. The results were validated by simu...

Automatic control of the depth of anesthesia-clinical results

This paper presents clinical results of the implementation of an automatic controller previously designed by the authors for the BIS level of patients subject to general anesthesia. Since the controller has a state feedback component, an observer is introduced in order to estimate state.

Reference Tracking of Depth of Anesthesia Using Optimal Control

Optimal control theory has gained increasing importance in biomedical applications, e.g., in the automatic administration of anesthetics during general anesthesia. In this context, one of the features that needs to be monitored is the depth of anesthesia. This is usually achieved by the joint administration of hypnotics and analgesics. The depth of anesthesia is quantified by the bispectral index that varies be...

Performance of an Adaptive Controller for the Neuromuscular Blockade Based on I...

An adaptive controller based on a minimally parameterized parsimonious Wiener model for the effect of the muscle relaxant rocuronium in the neuromuscular blockade is presented. The controller structure combines inversion of the recursively identified static nonlinearity of the Wiener model with a positive compartmental control law for the linearized system. The overall strategy exploits the fact that the model ...