8 documents found, page 1 of 1
A novel microfluidic system for 3D epidermis and full-thickness skin growth for...
Costa, Samanta; Carneiro, Ana Beatriz Machado; Lebre, Filipe; Meneses, João; Ainda, Alar; Moura, C.; Alfaro-Moreno, ErnestoChronic skin exposure to nanoparticles (NPs) from air pollution, cosmetics, tattoo inks, and smart textiles is linked to adverse effects such as accelerated aging, dermatitis, eczema, and increased melanoma risk. However, the limited predictive power and physiological relevance of conventional in vitro models, combined with the absence of standardized protocols for assessing NP toxicity, remain a major challenge...
Numerical modelling of mechanical and electromagnetic stimulation in bioreactor...
Meneses, JoãoIn Tissue Engineering (TE), bioreactors and scaffolds are paramount to promote and sustain adequate in vitro conditions for cell differentiation, proliferation, growth, and support. In addition to nutrient transport and waste removal, diverse bioreactor designs have been proposed to provide mechanical or electromagnetic stimuli to cells to enhance physical environmental conditions, significantly upregulating cr...
Eco-friendly flagging tape
Cordeiro, Rachel; Meneses, João; Dourado, Fernando; Pascoal-Faria, Paula; Moura, Carla; Alves, NunoOne of the problems of using commercial flagging tapes is that they are produced with non-degradable plastic and remain in the environment for long periods. To find a solution, an eco-friendly flagging tape was developed. Bacterial cellulose (BC) was used to produce a cellulose-based film and it was hypothesised that coating the tapes with a polymer would improve their resistance. So, two natural polymers (chit...
Nanosafety: an evolving concept to bring the safest possible nanomaterials to s...
Lebre, Filipa; Chatterjee, Nivedita; Costa, Samantha; Fernández-de-Gortari, Eli; Lopes, Carla; Meneses, João; Ortiz, Luís; Ribeiro, Ana R.The use of nanomaterials has been increasing in recent times, and they are widely used in industries such as cosmetics, drugs, food, water treatment, and agriculture. The rapid development of new nanomaterials demands a set of approaches to evaluate the potential toxicity and risks related to them. In this regard, nanosafety has been using and adapting already existing methods (toxicological approach), but the ...
Multifunctional bacterial cellulose-chitosan tape: an innovative substitute for...
Cordeiro, Rachel; Meneses, João; Dourado, Fernando; Veloso, Ana C. A.; Pascoal-Faria, Paula; Alves, Nuno; Moura, CarlaSynthetic polymers, generically named plastics, are manufactured from non-renewable sources, such as fossil fuels [1]. In 2020, 367 million metric tons of plastic were produced worldwide, and, only in 2018, global plastic waste volume reached 342.6 million metric tons [2,3]. One of the most used plastics is polyvinyl chloride (PVC), which is not environmentally friendly. The goal of this study was to achieve an...
How to correctly estimate the electric field in capacitively coupled systems fo...
Meneses, João; Fernandes, Sofia; Alves, Nuno; Pascoal-Faria, Paula; Miranda, Pedro CavaleiroCapacitively Coupled (CCoupled) electric fields are used to stimulate cell cultures in Tissue Engineering. Knowing the electric field (E-Field) magnitude in the culture medium is fundamental to establish a relationship between stimulus strength and cellular effects. We analysed eight CCoupled studies and sought to corroborate the reported estimates of the E-Field in the culture medium. First, we reviewed the ba...
A multimodal stimulation cell culture bioreactor for tissue engineering: A nume...
Meneses, João; Silva, João C.; Fernandes, Sofia R.; Datta, Abhishek; Ferreira, Frederico Castelo; Moura, Carla; Amado, Sandra; Alves, NunoThe use of digital twins in tissue engineering (TE) applications is of paramount importance to reduce the number of in vitro and in vivo tests. To pursue this aim, a novel multimodal bioreactor is developed, combining 3D design with numerical stimulation. This approach will facilitate the reproducibility between studies and the platforms optimisation (physical and digital) to enhance TE. The new bioreactor was ...
Iron Refractory Iron Deficiency Anemia in dizygotic twins due to a novel TMPRSS...
Pinto, Joana; Nobre de Jesus, Gustavo; Palma Anselmo, Mónica; Gonçalves, Lúcia; Brás, Daniela; Madeira Lopes, João; Meneses, João; Victorino, RuiIron refractory iron deficiency anemia (IRIDA) is an autosomal recessive ferropenic anemia. Its hypochromic microcytic pattern is associated with low transferrin saturation, normal-high ferritin, and inappropriately high hepcidin level. This entity is caused by mutants of the TMPRSS6 gene that encodes the protein matriptase II, which influences hepcidin expression, an iron metabolism counterregulatory protein. ...