7 documents found, page 1 of 1
Lipidomic profiling unveils sex differences in diabetes risk
Pina, Ana; Meneses, Maria João; Carli, Fabrizia; RT, Ribeiro; Gardete-Correia, Luís; Boavida, Ana; RAPOSO, JOÃO; Gastaldelli, Amalia; P Macedo, MPublisher Copyright: © 2025 The Author(s). European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.; Aims/Hypothesis: Type 2 diabetes is a multifactorial condition whose greatest impact comes from its complications. We hypothesized that distinct insulin-derived mechanisms and lipid profiles discriminate s...
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associa...
Coelho, Margarida; Patarrão, Rita S.; Sousa-Lima, Inês; Ribeiro, Rogério César de Almeida; Meneses, Maria João; Andrade, Rita; Mendes, Vera M.Coffee may protect against non-alcoholic fatty liver disease (NAFLD), but the roles of the caffeine and non-caffeine components are unclear. Coffee intake by 156 overweight subjects (87% with Type-2-Diabetes, T2D) was assessed via a questionnaire, with 98 subjects (all T2D) also providing a 24 h urine sample for quantification of coffee metabolites by LC-MS/MS. NAFLD was characterized by the fatty liver index (...
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associa...
Coelho, Margarida; Patarrão, Rita S.; Sousa-Lima, Inês; Ribeiro, Rogério T.; Meneses, Maria João; Andrade, Rita; Mendes, Vera M.; Manadas, BrunoCoffee may protect against non-alcoholic fatty liver disease (NAFLD), but the roles of the caffeine and non-caffeine components are unclear. Coffee intake by 156 overweight subjects (87% with Type-2-Diabetes, T2D) was assessed via a questionnaire, with 98 subjects (all T2D) also providing a 24 h urine sample for quantification of coffee metabolites by LC-MS/MS. NAFLD was characterized by the fatty liver index (...
Big data and machine learning to tackle diabetes management
Pina, Ana F; Meneses, Maria João; Sousa-Lima, Inês; Henriques, Roberto; Raposo, João F; Macedo, Maria PaulaType 2 Diabetes (T2D) diagnosis is based solely on glycaemia, even though it is an endpoint of numerous dysmetabolic pathways. Type 2 Diabetes complexity is challenging in a real-world scenario; thus, dissecting T2D heterogeneity is a priority. Cluster analysis, which identifies natural clusters within multidimensional data based on similarity measures, poses a promising tool to unravel Diabetes complexity.
Fibrosis nonalcoholic steatohepatitis index validation and applicability consid...
Pina, Ana; Meneses, Maria João; Ribeiro, Rogério César de Almeida; Raposo, João F; Macedo, Maria PaulaNonalcoholic fatty liver disease (NAFLD) diagnosis without using invasive methods is extremely challenging, highlighting the need for simple indexes for this end. Recently, the fibrotic nonalcoholic steatohepatitis index (FNI) was developed and proposed as an affordable non-invasive score calculated with aspartate aminotransferase, high-density lipoprotein cholesterol and haemoglobin A1c. Herein, and given the ...
Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases
Sousa, Luís; Guarda, Mariana; Meneses, Maria João; Macedo, M. Paula; Vicente Miranda, HugoInsulin-degrading enzyme (IDE) function goes far beyond its known proteolytic role as a regulator of insulin levels. IDE has a wide substrate promiscuity, degrading several proteins such as amyloid-β peptide, glucagon, islet amyloid polypeptide (IAPP), and insulin-like growth factors, which have diverse physiological and pathophysiological functions. Importantly, IDE plays other non-proteolytic functions such a...
Knockout of insulin-degrading enzyme leads to mice testicular morphological cha...
Meneses, Maria João; Borges, Diego O.; Dias, Tânia R.; Martins, Fátima O.; Oliveira, Pedro F.; Macedo, M. Paula; Alves, Marco G.Insulin-degrading enzyme (IDE) is a zinc metalloprotease responsible for degrading and inactivating several bioactive peptides, including insulin. Individuals without this enzyme or with a loss-of-function mutation in the gene that codifies it, present hyperinsulinemia. In addition, impairment of IDE-mediated insulin clearance is associated with the development of metabolic diseases, namely prediabetes. Althoug...