Introduction: Patients with chronic kidney disease (CKD) may present impaired functional capacity due to peripheral muscle involvement. Oxidative stress and inflammation are probably involved in this pathophysiology. This study aimed to evaluate the association between functional capacity and biomarkers of oxidative stress as well as biomarkers of inflammation in patients under chronic hemodialysis therapy. Met...
Leprosy may present kidney and endothelial abnormalities, being a risk factor for complications. However, the involvement of renal and vascular endothelia has been poorly investigated. We aimed to investigate if the levels of systemic endothelial biomarkers are associated with kidney abnormalities and the clinical forms of leprosy. This is a cross-sectional study with leprosy patients enrolled in January 2017 t...
Introduction: Hemodialysis (HD) patients have altered pulmonary function and this is associated with impaired endothelial function and cardiovascular events. Respiratory muscle training (RMT) has the potential to improve cardiovascular outcomes in patients undergoing maintenance HD. Here, we evaluated the e ff ects of RMT on endothelium/glycocalyx, oxidative stress biomarkers and pulmonary function test in HD p...
The use of amphotericin B is very effective for treatment of visceral leishmaniasis (VL), but it is one of the main causes of acute kidney injury (AKI) in these patients. The liposomal formulation has less nephrotoxicity, but few studies with renal biomarkers have been done evaluating these effects in patients with VL. Aims: To study the association of the use of liposomal Anf-B with renal injury in patients wi...
Background: Kidney injury associated with the use of anabolic androgenic steroids (AAS) has been described. The aim of the study was to investigate new kidney injury biomarkers among bodybuilders using anabolic androgenic steroids (AAS). Methods: A cross-sectional study was conducted with a group of AAS users (n = 28) and a group of non-users (n = 29). Blood and urine samples were collected for analysis, includ...