4 documents found, page 1 of 1
Vasoactive intestinal peptide degradation might influence Interleukin-17 expres...
Pereira, Francielle Beltrão; Dutra, Walderez O.; Gollob, Kenneth J.; Reis, Edna Afonso; Oliveira, Ana Laura Grossi de; Rocha, Manoel Otávio da CostaThe vasoactive intestinal peptide (VIP) expression is lower in cardiac chagasic patients and is related to worse cardiac function. The reduction of VIP in patients with Chagas disease may be a result of its enhanced degradation. To test this hypothesis, the tryptase and chymase expression was evaluated. We also related VIP levels with interleukin-17 (IL17) expression since VIP may modulate IL-17 production. Pla...
Vasoactive intestinal peptide reduces the inflammatory profile in mice infected...
Higyno, Pulchéria Maria Silva; Mendes, Priscila Fagundes; Miranda, Marina Barcelos de; Pereira, Dario Elias; Mota, Ana Paula LucasVasoactive intestinal peptide (VIP) has gained great prominence because of its therapeutic potential, which is ascribed to its ability to regulate innate immunity, inhibit antigen-specific Th1 cell responses, and generate T regulatory cells. Additionally, VIP may act as a natural antimicrobial peptide, killing bacteria, fungi, and infective forms of Trypanosoma brucei. Despite the possible relevance of VIP duri...
Temporal analysis of oxidative effects on the pulmonary inflammatory response i...
Campos, Keila Karine Duarte; Manso, Rafaela Gontijo; Gonçalves, Evandro Guedes; Silva, Marcelo Eustáquio; Lima, Wanderson Geraldo deThe most common factor related to the chronic obstructive pulmonary disease (COPD) development is the chronic smoking habit. Our study describes the temporal kinesis of pulmonary cellular influx through BALF analyses of mice acutely exposed to cigarette smoke (CS), the oxidative damage and antioxidative enzyme activities. Thirty-six mice (C57BL/6, 8 weeks old, male) were divided in 6 groups: the control group (...
Low levels of vasoactive intestinal peptide are associated with Chagas disease ...
Corrêa, Marielle Valério; Rocha, Manoel Otávio da Costa; Sousa, Giovane Rodrigo de; Nunes, Maria do Carmo Pereira; Gollob, Kenneth JohnThe interconnection between immune and neuroendocrine systems influences regulation of inflammatory responses. The possible relevance that this integrative response may have during the course of Chagas disease remains poorly characterized. In this context, our study was designed to determine the expression of vasoactive intestinal peptide (VIP), a neuropeptide with anti-inflammatory properties, in blood from th...