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Role of the renin angiotensin system in blood pressure allostasis-induced by se...
Souza, Aline Maria Arlindo de; West, Crystal A.; Abreu, Aline Rezende Ribeiro de; Pai, Amrita V.; Mesquita, Laura Batista Tavares; Ji, HongSevere food restriction (FR) is associated with blood pressure (BP) and cardiovascular dysfunction. The renin-angiotensin system (RAS) regulates BP and its dysregulation contributes to impaired cardiovascular function. Female Fischer rats were maintained on a control (CT) or severe FR (40% of CT) diet for 14 days. In response to severe FR, BP allostasis was achieved by up-regulating circulating Ang-[1–8] by 1.3...
New insights on amygdala : basomedial amygdala regulates the physiological resp...
Mesquita, Laura Batista Tavares; Abreu, Aline Rezende Ribeiro de; Abreu, Alessandra Rezende Ribeiro de; Souza, Aline Maria Arlindo deThe amygdala has been associated with a variety of functions linked to physiological, behavioral and endocrine responses during emotional situations. This brain region is comprised of multiple sub-nuclei. These subnuclei belong to the same structure, but may be involved in different functions, thereby making the study of each sub-nuclei important. Yet, the involvement of the basomedial amygdala (BMA) in the reg...
High-Fat diet increases HMGB1 expression and promotes lung inflammation in mice...
Souza, Ana Beatriz Farias de; Chírico, Máira Tereza Talma; Cartelle, Christiane Teixeira; Costa, Guilherme de Paula; Silva, André Talvani Pedrosa daThis study aims to evaluate the effects of a high-fat diet and mechanical ventilation on the pulmonary and systemic inflammatory response in C57BL/6 mice. Male C57BL/6 mice were divided into two groups: one received a standard diet, and the other received a high-fat diet. After 10 weeks, the groups were further divided into two groups each: control group (CG), mechanical ventilation group (MVG), diet group (DG)...
Chronic treatment with ivabradine does not affect cardiovascular autonomic cont...
Silva, Fernanda Cacilda dos Santos; Paiva, Franciny Aparecida; Ribeiro, Flavia Camargos de Figueiredo Müller; Caldeira, Henrique Martins ArantesA low resting heart rate (HR) would be of great benefit in cardiovascular diseases. Ivabradine-a novel selective inhibitor of hyperpolarization-activated cyclic nucleotide gated (HCN) channels- has emerged as a promising HR lowering drug. Its effects on the autonomic HR control are little known. This study assessed the effects of chronic treatment with ivabradine on the modulatory, reflex and tonic cardiovascul...
Tobacco-free cigarette smoke exposure induces anxiety and panic-related behavio...
Chírico, Máira Tereza Talma; Bezerra, Frank Silva; Guedes, Mariana Reis; Souza, Ana Beatriz Farias de; Silva, Fernanda Cacilda dos SantosSmokers, who generally present with lung damage, are more anxious than non-smokers and have an associated augmented risk of panic. Considering that lung damage signals specific neural pathways that are related to affective responses, the aim of the present study was to evaluate the influence of pulmonary injury on anxiety and panic-like behaviours in animals exposed to cigarette smoke with and without tobacco. ...
Nitric oxide modulates blood pressure through NMDA receptors in the rostral ven...
Machado, Natália Lima Santos; Silva, Fernanda Cacilda dos Santos; Chianca Júnior, Deoclécio Alves; Menezes, Rodrigo Cunha Alvim deThe rostral ventrolateral medulla (RVLM) is an important site of cardiovascular control related to the tonic excitation and regulating the sympathetic vasomotor tone through local presympathetic neurons. Nitric oxide (NO) has been implicated in the modulation of neurotransmission by several areas of the central nervous system including the RVLM. However the path ways driving NO affects and the correlation betwe...
The role of dorsomedial hypotalamus ionotropic glutamate receptors in the hyper...
Silva, Fernanda Cacilda dos Santos; Guidine, Patrícia Alves Maia; Machado, Natália Lima Santos; Xavier, Carlos Henrique; Menezes, Rodrigo Cunha Alvim deThe scorpion envenoming syndrome is an important worldwide public health problem due to its high incidence and potential severity of symptoms. Some studies address the high sensitivity of the central nervous system to this toxin action. It is known that cardiorespiratory manifestations involve the activation of the autonomic nervous system. However, the origin of this modulation remains unclear. Considering the...
Increased α1-adrenoreceptor activity is required to sustain blood pressure in f...
Souza, Aline Maria Arlindo de; Menezes, Rodrigo Cunha Alvim de; Abreu, Aline Rezende Ribeiro de; Araujo, Glaucy Rodrigues de; Costa, Daniela CaldeiraAims: Weevaluated the effect of food restriction (FR) on the various reflexes involved in short termcardiovascular regulation; we also evaluated the contribution of the sympathetic nervous systemand of the plasmatic nitric oxide (NO) in the development of the counterregulatory cardiovascular changes triggered by FR. Main methods: Female rats were subjected to FR for 14 days, and after this period biochemical me...
Amygdalar neuronal activity mediates the cardiovascular responses evoked from t...
Abreu, Alessandra Rezende Ribeiro de; Santos, Laura Gomes Batista Tavares; Souza, Aline Maria Arlindo de; Silva, L. G. daThere is ample evidence that both lateral/ dorsolateral periaqueductal gray (l/dlPAG) and basolateral amygdala (BLA) are essential for the regulation of the autonomic responses evoked during innate reactions to threatening stimuli. However, it is not well established to what extent the BLA regulates the upstream functional connection from the l/dlPAG. Here we evaluated the role of the BLA and its glutamatergic ...
Sympathetic cutaneous vasomotor alerting responses (SCVARs) are associated with...
Menezes, Rodrigo Cunha Alvim de; Ootsuka, Youichirou; Blessing, William W.Alerting stimuli that cause sympathetic cutaneous vasomotor alerting responses (“SCVARs”) in the thermoregulatory vascular bed of the rabbit ear pinna also induce theta (5–8 Hz) rhythm in the hippocampal EEG, a marker that the animal is engaged with the environment. The present study determines the relation between SCVARs in the thermoregulatory tail artery vascular bed and hippocampal EEG theta rhythm in Sprag...