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The prognostic impact of TERT promoter mutations in glioblastomas is modified b...
Batista, Rui; Cruvinel-Carloni, Adriana; Vinagre, João; Peixoto, Joana; Catarino, Telmo A.; Campanella, Nathalia Cristina; Menezes, WederHuman hotspot TERT promoter (TERTp) mutations have been reported in a wide range of tumours. Several studies have shown that TERTp mutations are associated with clinicopathological features; in some instances, TERTp mutations were considered as biomarkers of poor prognosis. The rs2853669 SNP, located in the TERT promoter region, was reported to modulate the increased TERT expression levels induced by the recurr...
Date: 2016
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Origin: RepositóriUM - Universidade do Minho