17 documents found, page 1 of 2
P-selectin glycoprotein ligand 1 promotes T cell lymphoma development and disse...
Pereira, JL; Cavaco, P; Silva, RC; Pacheco-Leyva, I; Mereiter, S; Pinto, R; Reis, CA; Santos, NRP-selectin glycoprotein ligand-1 (PSGL-1) is a membrane-bound glycoprotein expressed in lymphoid and myeloid cells. It is a ligand of P-, E- and L-selectin and is involved in T cell trafficking and homing to lymphoid tissues, among other functions. PSGL-1 expression has been implicated in different lymphoid malignancies, so here we aimed to evaluate the involvement of PSGL-1 in T cell lymphomagenesis and dissem...
Mycobacterium tuberculosis infection up-regulates sialyl lewis x expression in ...
Matos, R; Fonseca, KL; Mereiter, S; Maceiras, AR; Gomes, J; Vilaplana, C; Gärtner, F; Rodrigues, P; Reis, CA; Saraiva, M; Magalhães, AGlycans display increasingly recognized roles in pathological contexts, however, their impact in the host-pathogen interplay in many infectious diseases remains largely unknown. This is the case for tuberculosis (TB), one of the ten most fatal diseases worldwide, caused by infection of the bacteria Mycobacterium tuberculosis. We have recently reported that perturbing the core-2 O-glycans biosynthetic pathway in...
Analysis of the effect of increased a2,3-sialylation on RTK activation in MKN45...
Balmaña, M; Diniz, F; Feijão, T; Barrias, CC; Mereiter, S; Reis, CAIn the scenario of personalized medicine, targeted therapies are currently the focus of cancer drug development. These drugs can block the growth and spread of tumor cells by interfering with key molecules involved in malignancy, such as receptor tyrosine kinases (RTKs). MET and Recepteur d’Origine Nantais (RON), which are RTKs frequently overactivated in gastric cancer, are glycoprotein receptors whose activat...
Author Correction: iLoF: An intelligent Lab on Fiber Approach for Human Cancer ...
Paiva, JS; Jorge, PAS; Ribeiro, RSR; Balmaña, M; Campos, D; Mereiter, S; Jin, C; Karlsson, NG; Sampaio, P; Reis, CA; Cunha, JPSAn amendment to this paper has been published and can be accessed via a link at the top of the paper.
iLoF: An intelligent Lab on Fiber Approach for Human Cancer Single-Cell Type Id...
Paiva, JS; Jorge, PAS; Ribeiro, RSR; Balmaña, M; Campos, D; Mereiter, S; Jin, C; Karlsson, NG; Sampaio, P; Reis, CA; Cunha, JPSWith the advent of personalized medicine, there is a movement to develop “smaller” and “smarter” microdevices that are able to distinguish similar cancer subtypes. Tumor cells display major differences when compared to their natural counterparts, due to alterations in fundamental cellular processes such as glycosylation. Glycans are involved in tumor cell biology and they have been considered to be suitable can...
O-glycans truncation modulates gastric cancer cell signaling and transcription ...
Freitas, D; Campos, D; Gomes, J; Pinto, F; Macedo, JA; Matos, R; Mereiter, S; Pinto, MT; Polónia, A; Gärtner, F; Magalhães, A; Reis, CABackground: Changes in glycosylation are known to play critical roles during gastric carcinogenesis. Expression of truncated O-glycans, such as the Sialyl-Tn (STn) antigen, is a common feature shared by many cancers and is associated with cancer aggressiveness and poor-prognosis. Methods: Glycoengineered cell lines were used to evaluate the impact of truncated O-glycans in cancer cell biology using in vitro fun...
O-glycan truncation enhances cancer-related functions of CD44 in gastric cancer.
Mereiter, S; Macedo, JA; Polom, K; Roviello, F; Magalhães, A; Reis, CACD44 isoforms are often upregulated in gastric cancer and have been associated with increased metastatic potential and poor survival. To evaluate the functional impact of O-glycan truncation on CD44 we have analysed glyco-engineered cancer cell models displaying shortened O-glycans. Here, we demonstrate that induction of aberrant O-glycan termination through various molecular mechanisms affects CD44 molecular f...
Hypoxia and serum deprivation induces glycan alterations in triple negative bre...
Albuquerque, AP; Balmaña, M; Mereiter, S; Pinto, F; Reis, CA; Beltrão, EICTriple negative breast cancer (TNBC) is a major global public health problem. The lack of targeted therapy and the elevated mortality evidence the need for better knowledge of the tumor biology. Hypoxia and aberrant glycosylation are associated with advanced stages of malignancy, tumor progression and treatment resistance. Importantly, serum deprivation regulates the invasive phenotype and favors TNBC cell surv...
Glycosylation in cancer: Selected roles in tumour progression, immune modulatio...
Rodrigues, JG; Balmaña, M; Macedo, JA; Poças, J; Fernandes, Â; Freitas-Junior, JCM; Pinho, SS; Gomes, J; Magalhães, A; Gomes, C; Mereiter, S; Reis, CATumour metastasis is the main cause of cancer related deaths. Metastasis is an intricate multi-step process that requires the acquisition of several cancer cell features, including the modulation of tumour cell migration, adhesion, invasion, and immune evasion. Changes in the cellular glycosylation are associated with malignant transformation of cancer cells, tumour progression and ultimately, metastasis format...
Multicellular Human Gastric Cancer Spheroids Mimic the Glycosylation Phenotype ...
Balmaña, M; Mereiter, S; Diniz, F; Feijão, T; Barrias, CC; Reis, CACellular glycosylation plays a pivotal role in several molecular mechanisms controlling cell⁻cell recognition, communication, and adhesion. Thus, aberrant glycosylation has a major impact on the acquisition of malignant features in the tumor progression of patients. To mimic these in vivo features, an innovative high-throughput 3D spheroid culture methodology has been developed for gastric cancer cells. The ass...