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Glutamine and Alanyl-Glutamine increase RhoA expression and reduce clostridium ...

Santos, Ana Angélica Queiroz Assunção; Braga Neto, Manuel Bonfim; Oliveira, Marcelo Róseo de; Freire, Rosemayre Souza; Barros, Eduardo Bedê

Clostridium difficile is a major cause of antibiotic-associated colitis and is associated with signicant morbidity and mortality. Glutamine (Gln) is a major fuel for the intestinal cell population. Alanyl-glutamine (Ala-Gln) is a dipeptide that is highly soluble and well tolerated. IEC-6 cells were used in the in vitro experiments. Cell morphology was evaluated by atomic force microscopy (AFM) and scanning elec...

Date: 2020   |   Origin: Oasisbr

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