5 documents found, page 1 of 1
Crosslinking immunity and metabolism during Leishmania infection
Mesquita, Inês MoraisAs escolhas metabólicas condicionam a função das células imunes e o decorrer da infeção. Os agentes patogénicos evoluíram com os hospedeiros, desenvolvendo estratégias para aumentar a sobrevivência através do bloqueio das capacidades microbicidas do hospedeiro: através do sequestro do metabolismo do hospedeiro e controlo da polarização de células imunes. Observou-se que na ausência do fator HIF-1a ocorria um au...
Obesity effects on muscular activity during lifting and lowering tasks
Colim, Ana S.; Arezes, P.; Flores, Paulo; Monteiro, Pedro Ribeiro Rocha; Mesquita, Inês Morais; Braga, A. C.Obesity is an emerging health problem and its incidence has been increasing throughout the workforce. In industrial workstations, vertical handling tasks (VHT), including lifting and lowering, are very common and can cause a significant muscular overload for the involved workers. During these tasks, muscular activity may be considerably affected by workers' body conditions. This study aims to analyze and compar...
The impact of IL-10 dynamic modulation on host immune response against visceral...
Mesquita, Inês Morais; Ferreira, Carolina; Barbosa, Ana Margarida; Ferreira, Catarina Machado; Moreira, Diana; Carvalho, Agostinho; Cunha, CristinaLeishmaniasis is a vector-borne disease caused by protozoan parasites from the genus Leishmania. The most severe form of disease is visceral leishmaniasis (VL), which is fatal if left untreated. It has been demonstrated that interleukin (IL)-10, is associated with disease progression and susceptibility. In this work, we took advantage of a transgenic mouse model that expresses high levels of IL-10 upon zinc sul...
AMPK in Pathogens
Mesquita, Inês Morais; Moreira, Diana; Marques, Belém Sampaio; Laforge, Mireille; Cordeiro-da-Silva, Anabela; Ludovico, Paula; Estaquier, JérômeDuring host–pathogen interactions, a complex web of events is crucial for the outcome of infection. Pathogen recognition triggers powerful cellular signaling events that is translated into the induction and maintenance of innate and adaptive host immunity against infection. In opposition, pathogens employ active mechanisms to manipulate host cell regulatory pathways toward their proliferation and survival. Amon...
Exploring NAD(+) metabolism in host-pathogen interactions
Belinha, Ana; Gaifem, Joana; Mesquita, Inês Morais; Silvestre, Ricardo Jorge LealNicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate. The regulation of NAD+ metabolism has proven to be an adequate drug target for several diseases, including cancer, neurodegenerative or inflammatory diseases. Increasi...