Abatacept is a recombinant protein that has been approved for the treatment of rheumatoid arthritis. This drug selectively modulates the costimulatory signal necessary to activate T lymphocytes, reducing the expression of pro-inflammatory cytokines. However, secondary effects such as increased bone deposition, delayed healing of oral ulcers, and reduced angiogenesis and endothelial adhesion have been observed, ...
O câncer é considerado a segunda maior causa de morte no mundo por doença. Segundo o Instituto Nacional do Câncer, no nordeste brasileiro, o câncer oral é a quinta malignidade mais comum em homens e a nona em mulheres. Para o ano de 2016 são esperados 15.460 novos casos no Brasil. O cirurgião dentista possui um importante papel no diagnóstico clínico patológico destas lesões, na promoção de saúde e reabilitação...
Abatacept is known for the regulation of T cell activation and modulation of inflammatory cytokines, and due to this to mechanisms it may interferes on wound healing. The aim of this study was to evaluate the ulcer’s healing process on buccal mucosa of males Wistar rats administered with Abatacept subcutaneously. The rats were randomized between a control group, injected with saline subcutaneously, and other th...