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Ezrin protein’s role on cell migration in gastric cancer and identification of ...
Silva , Sara; Mesquita, Patrícia; Pereira, Bruno; Almeida, RaquelBackground: Gastric cancer (GC) is the fourth leading cause of cancer-related deaths, often diagnosed in late stages of the disease, limiting treatment options [1-2]. The absence of new therapies and proper diagnosis calls for an exploration of different potential targets. Epitranscriptomics studies RNA chemical modifications such as N6-methyladenosine (m6A), lately studied to understand its effect on cancer pr...
High-Throughput Drug Screening Revealed That Ciclopirox Olamine Can Engender Ga...
Pádua, Diana; Figueira, Paula; Pinto, Mariana; Maia, André Filipe; Peixoto, Joana; Lima, Raquel T; Pombinho, António; Pereira, Carlos FilipeCancer stem cells (CSCs) are relevant therapeutic targets for cancer treatment. Still, the molecular circuits behind CSC characteristics are not fully understood. The low number of CSCs can sometimes be an obstacle to carrying out assays that explore their properties. Thus, increasing CSC numbers via small molecule-mediated cellular reprogramming appears to be a valid alternative tool. Using the SORE6-GFP repor...
HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer
Pádua, Diana; Pinto, Débora Filipa; Figueira, Paula; Pereira, Carlos Filipe; Almeida, Raquel; Mesquita, PatríciaGastric cancer is a serious health problem worldwide. Although its incidence is decreasing, the five-year survival rate remains low. Thus, it is essential to identify new biomarkers that could promote better diagnosis and treatment of patients with gastric cancer. High-mobility group AT-hook 1 (HMGA1) is a non-histone, chromatin-binding protein that has been found overexpressed in several tumor types. It has be...
A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to M...
Pádua, Diana; Barros, Rita; Amaral, Ana Luísa; Mesquita, Patrícia; Freire, Ana Filipa; Sousa, Mafalda; Maia, André Filipe; Caiado, Inês; Fernandes, HugoGastric cancer remains a serious health burden with few therapeutic options. Therefore, the recognition of cancer stem cells (CSCs) as seeds of the tumorigenic process makes them a prime therapeutic target. Knowing that the transcription factors SOX2 and OCT4 promote stemness, our approach was to isolate stem-like cells in human gastric cancer cell lines using a traceable reporter system based on SOX2/OCT4 acti...