3 documents found, page 1 of 1
Lipocalin-2 is involved in emotional behaviors and cognitive function
Ferreira, Ana Catarina; Pinto, Vítor; Mesquita, Sandro; Novais, Ashley Cruz; Sousa, João Carlos; Neves, Margarida Correia; Sousa, NunoLipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display anxious and depressive-like behaviors, as well as cognitive impairment in ...
Lipocalin 2 is present in the EAE brain and is modulated by natalizumab
Marques, Fernanda; Mesquita, Sandro; Sousa, João; Coppola, Giovanni; Gao, Fuying; Geschwind, Daniel H.; Columba-Cabezas, Sandra; Aloisi, FrancescaMultiple sclerosis (MS) is a demyelinating disease that causes major neurological disability in young adults. A definitive diagnosis at the time of the first episode is still lacking, but since early treatment leads to better prognosis, the search for early biomarkers is needed. Here we characterized the transcriptome of the choroid plexus (CP), which is part of the blood-brain barriers (BBBs) and the major sit...
Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of...
Mesquita, Sandro; Ferreira, A. C.; Sousa, João Carlos; Santos, Nadine Correia; Neves, Margarida Correia; Sousa, Nuno; Palha, Joana AlmeidaIron is essential for mammalian cellular homeostasis. However, in excess, it promotes free radical formation and is associated with aging-related progressive deterioration and with neurodegenerative disorders such as Alzheimer's disease (AD). There are no mechanisms to excrete iron, which makes iron homeostasis a very tightly regulated process at the level of the intestinal absorption. Iron is believed to reach...