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The mediating role of combined lifestyle factors on the relationship between ed...

Alicandro, G; Bertuccio, P; Collatuzzo, G; Pelucchi, C; Bonzi, R; Liao, LM; Rabkin, CS; Sinha, R; Negri, E; Dalmartello, M; Zaridze, D; Maximovich, D

Background: The causal pathway between high education and reduced risk of gastric cancer (GC) has not been explained. The study aimed at evaluating the mediating role of lifestyle factors on the relationship between education and GC Methods: Ten studies with complete data on education and five lifestyle factors (smoking, alcohol drinking, fruit and vegetable intake, processed meat intake and salt consumption) w...


The Association between Peptic Ulcer Disease and Gastric Cancer: Results from t...

Paragomi, P; Dabo, B; Pelucchi, C; Bonzi, R; Bako, AT; Sanusi, NM; Nguyen, QH; Zhang, Z-F; Palli, D; Ferraroni, M; Vu, KT; Yu, G-P; Turati, F

Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach c...


Salt intake and gastric cancer: a pooled analysis within the Stomach cancer Poo...

Morais, S; Costa, A; Albuquerque, G; Araújo, N; Pelucchi, C; Rabkin, CS; Liao, LM; Sinha, R; Zhang, Z-F; Hu, J; Johnson, KC; Palli, D; Ferraroni, M

Purpose: Previous studies show that consuming foods preserved by salting increases the risk of gastric cancer, while results on the association between total salt or added salt and gastric cancer are less consistent and vary with the exposure considered. This study aimed to quantify the association between dietary salt exposure and gastric cancer, using an individual participant data meta-analysis of studies pa...


The association between diabetes and gastric cancer: results from the Stomach C...

Dabo, B; Pelucchi, C; Rota, M; Jain, H; Bertuccio, P; Bonzi, R; Palli, D; Ferraroni, M; Zhang, Z-F; Sanchez-Anguiano, A; Thi-Hai, Pham, Y

Background Prior epidemiologic studies on the association between diabetes and gastric cancer risk provided inconclusive findings, while traditional, aggregate data meta-analyses were characterized by high between-study heterogeneity. Objective To investigate the association between type 2 diabetes and gastric cancer using data from the 'Stomach Cancer Pooling (StoP) Project', an international consortium of mor...


Coffee consumption and gastric cancer: A pooled analysis from the Stomach cance...

Martimianaki, G; Bertuccio, P; Alicandro, G; Pelucchi, C; Bravi, F; Carioli, G; Bonzi, R; Rabkin, CS; Liao, LM; Sinha, R; Johnson, K; Hu, J; Palli, D

Objective This study aimed to evaluate and quantify the relationship between coffee and gastric cancer using a uniquely large dataset from an international consortium of observational studies on gastric cancer, including data from 18 studies, for a total of 8198 cases and 21 419 controls. Methods A two-stage approach was used to obtain the pooled odds ratios (ORs) and the corresponding 95% confidence intervals ...


Fruits and vegetables intake and gastric cancer risk: A pooled analysis within ...

Ferro, A; Costa, AR; Morais, S; Bertuccio, P; Rota, M; Pelucchi, C; Hu, J; Johnson, KC; Zhang, ZF; Palli, D; Ferraroni, M; Yu, GP; Bonzi, R

A low intake of fruits and vegetables is a risk factor for gastric cancer, although there is uncertainty regarding the magnitude of the associations. In our study, the relationship between fruits and vegetables intake and gastric cancer was assessed, complementing a previous work on the association betweenconsumption of citrus fruits and gastric cancer. Data from 25 studies (8456 cases and 21 133 controls) with...


Meat intake and risk of gastric cancer in the Stomach cancer Pooling (StoP) pro...

Ferro, A; Rosato, V; Rota, M; Costa, AR; Morais, S; Pelucchi, C; Johnson, KC; Hu, J; Palli, D; Ferraroni, M; Zhang, ZF; Bonzi, R; Yu, GP; Peleteiro, B

The consumption of processed meat has been associated with noncardia gastric cancer, but evidence regarding a possible role of red meat is more limited. Our study aims to quantify the association between meat consumption, namely white, red and processed meat, and the risk of gastric cancer, through individual participant data meta-analysis of studies participating in the “Stomach cancer Pooling (StoP) Project”....


Education and gastric cancer risk-An individual participant data meta-analysis ...

Rota, M; Alicandro, G; Pelucchi, C; Bonzi, R; Bertuccio, P; Hu, J; Zhang, ZF; Johnson, KC; Palli, D; Ferraroni, M; Yu, GP; Galeone, C; López-Carrillo, L

Low socioeconomic position (SEP) is a strong risk factor for incidence and premature mortality from several cancers. Our study aimed at quantifying the association between SEP and gastric cancer (GC) risk through an individual participant data meta-analysis within the “Stomach cancer Pooling (StoP) Project”. Educational level and household income were used as proxies for the SEP. We estimated pooled odds ratios...


Citrus fruit intake and gastric cancer: The stomach cancer pooling (StoP) proje...

Bertuccio, P; Alicandro, G; Rota, M; Pelucchi, C; Bonzi, R; Galeone, C; Bravi, F; Johnson, KC; Hu, J; Palli, D; Ferraroni, M; López-Carrillo, L

Diets rich in vegetables and fruit have been associated with reduced risk of gastric cancer, and there is suggestive evidence that citrus fruits have a protective role. Our study aimed at evaluating and quantifying the association between citrus fruit intake and gastric cancer risk. We conducted a one-stage pooled analysis including 6,340 cases and 14,490 controls from 15 case–control studies from the stomach c...


Alcohol intake and gastric cancer: Meta-analyses of published data versus indiv...

Ferro, A; Morais, S; Rota, M; Pelucchi, C; Bertuccio, P; Bonzi, R; Galeone, C; Zhang, ZF; Matsuo, K; Ito, H; Hu, J; Johnson, KC; Yu, GP; Palli, D

Background: Individual participant data pooled analyses allow access to non-published data and statistical reanalyses based on more homogeneous criteria than meta-analyses based on systematic reviews. We quantified the impact of publication-related biases and heterogeneity in data analysis and presentation in summary estimates of the association between alcohol drinking and gastric cancer. Methods: We compared ...


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